
SPINK1 - Wikipedia
Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded …
SPINK1 Gene - GeneCards | ISK1 Protein | ISK1 Antibody
2024年12月25日 · SPINK1 (Serine Peptidase Inhibitor Kazal Type 1) is a Protein Coding gene. Diseases associated with SPINK1 include Tropical Calcific Pancreatitis and Pancreatitis, …
Functional Roles of SPINK1 in Cancers - PMC - PubMed Central …
Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease inhibitor of trypsin in the pancreas. However, emerging evidence shows its function in …
SPINK1-induced tumor plasticity provides a therapeutic window …
2023年11月29日 · Functionally, SPINK1 overexpression promotes tumor initiation, self-renewal, and chemoresistance by driving a deregulated EGFR-ERK-CDK4/6-E2F2 signaling axis to …
Functional Roles of SPINK1 in Cancers - PubMed
2021年4月7日 · Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease inhibitor of trypsin in the pancreas. However, emerging evidence shows its function …
Science子刊:又一关键机制被找到 并有希望逆转耐药性-健康界
2020年1月7日 · 丝氨酸蛋白酶抑制因子Kazal1型(serine protease inhibitor Kazal type 1,SPINK1)由胰腺的腺泡细胞分泌,SPINK1可通过阻止胰腺蛋白酶的激活来保护胰腺不被自身消化。通过 …
Targeting SPINK1 in the damaged tumour microenvironment …
2018年10月17日 · Here we report serine protease inhibitor Kazal type I (SPINK1), a SASP factor produced in human stromal cells after genotoxic treatment. DNA damage causes SPINK1 …
SPINK1 serine peptidase inhibitor Kazal type 1 [ (human)]
Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a …
丝氨酸肽酶抑制因子 Kazal 1 型(SPINK1)基因 | MCE
该基因编码的蛋白质是胰蛋白酶抑制剂,由胰腺腺泡细胞分泌到胰液中。 它被认为在预防胰腺和胰管内胰蛋白酶催化的酶原过早激活方面起作用。 该基因的突变与遗传性胰腺炎和热带钙化性 …
Nat Comm丨 孙宇组发现肿瘤微环境中衰老细胞触发临床治疗抵抗 …
为了抵消随着化疗的进行而出现的肿瘤微环境中的SPINK1,研究人员使用了SPINK1的单克隆抗体,以及已被美国FDA批准的、临床中用于阻断EGFR的西妥昔单抗Cetuximab。
- 某些结果已被删除