Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded …

2024年12月25日 · SPINK1 (Serine Peptidase Inhibitor Kazal Type 1) is a Protein Coding gene. Diseases associated with SPINK1 include Tropical Calcific Pancreatitis and Pancreatitis, …

Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease inhibitor of trypsin in the pancreas. However, emerging evidence shows its function in …

2023年11月29日 · Functionally, SPINK1 overexpression promotes tumor initiation, self-renewal, and chemoresistance by driving a deregulated EGFR-ERK-CDK4/6-E2F2 signaling axis to …

2021年4月7日 · Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease inhibitor of trypsin in the pancreas. However, emerging evidence shows its function …

2020年1月7日 · 丝氨酸蛋白酶抑制因子Kazal1型(serine protease inhibitor Kazal type 1,SPINK1)由胰腺的腺泡细胞分泌，SPINK1可通过阻止胰腺蛋白酶的激活来保护胰腺不被自身消化。通过 …

2018年10月17日 · Here we report serine protease inhibitor Kazal type I (SPINK1), a SASP factor produced in human stromal cells after genotoxic treatment. DNA damage causes SPINK1 …

Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a …

该基因编码的蛋白质是胰蛋白酶抑制剂，由胰腺腺泡细胞分泌到胰液中。 它被认为在预防胰腺和胰管内胰蛋白酶催化的酶原过早激活方面起作用。 该基因的突变与遗传性胰腺炎和热带钙化性 …

为了抵消随着化疗的进行而出现的肿瘤微环境中的SPINK1，研究人员使用了SPINK1的单克隆抗体，以及已被美国FDA批准的、临床中用于阻断EGFR的西妥昔单抗Cetuximab。