2024年12月25日 · SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Pediatric Systemic Lupus Erythematosus and Dentin Dysplasia. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and extracellular matrix binding.

SPP1 as a key gene in the lymph node metastasis and a potential predictor of poor prognosis in head and neck carcinoma. Alternative polyadenylation mechanism links secreted phosphoprotein 1 gene to glioblastoma.

SPP1 is a prognostic marker in Cervical squamous cell carcinoma and endocervical adenocarcinoma, Liver hepatocellular carcinoma, Lung adenocarcinoma, Pancreatic adenocarcinoma

2022年4月22日 · Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein-1 (SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that functions not only in intercellular communication, but also in …

2023年8月3日 · The CXCL9:SPP1 ratio could characterize the abundance of antitumor immune cells in cancer, gene expression programs in each tumor-infiltrating cell type, the regulation of communication networks that dictate tumor control or progression, and the response to immunotherapy. —Priscilla N. Kelly

2025年2月8日 · The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein.

Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineral ized matrix. Probably important to cell-matrix interaction.... show less. Keywords assigned by UniProt to proteins due to their particular molecular function.

We will systematically analyze SPP1 expression levels and their association with patient prognosis and immunotherapeutic responses, aiming to reveal the potential of SPP1 as a novel immunotherapeutic target.

Osteopontin (SPP1, a secreted phosphoprotein 1) is primarily involved in immune responses, tissue remodelling and biomineralization. However, it is also overexpressed in many cancers and regulates tumour progression by increasing migration, invasion and cancer stem cell self-renewal.

2025年2月8日 · Title: A comprehensive single-cell RNA transcriptomic analysis identifies a unique SPP1+ macrophages subgroup in aging skeletal muscle. SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages.