Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.

Sterol-regulatory element binding proteins (SREBPs)胆固醇调节元件结合蛋白(SREBP)是位于内质网的细胞内胆固醇敏感器，通过Insig-Srebp-Scap途径对细胞内胆固醇进行反馈调节。

SREBP-1c is responsible for regulating the genes required for de novo lipogenesis. [6] SREBP-2 regulates the genes of cholesterol metabolism. [6] SREB proteins are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. These proteins work with asymmetric sterol regulatory element (StRE).

2024年12月25日 · SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1) is a Protein Coding gene. Diseases associated with SREBF1 include Ifap Syndrome 2 and Mucoepithelial Dysplasia, Hereditary. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism of steroids.

SREBP1（固醇调节元件结合蛋白1）是调控脂合成的重要转录调控因子，其合成后以非活性前体的形式存在于内质网。 当固醇浓度低时，SREBP1以依赖于COPII的方式从内质网转运到高尔基体，并在高尔基体受蛋白酶加工剪切。 加工成熟后的SREBP1进入细胞核，诱导胆固醇合成和脂质稳态维持相关基因的表达。 进入细胞核的SREBP1会迅速地经历泛素化修饰，随后被蛋白酶降解。 研究表明人源异构体SREBP-1A的转录活性高于 SREBP-1C，前者能够刺激脂肪酸和胆固醇 …

该文总结了受SREBP-1调控表达的靶基 因的特点, 着重介绍了胰岛素等上游因子在SREBP-1调控过程中的作用, 为指导治疗各类代谢性疾 病提供新的思路。 关键词 SREBP-1; 胰岛素; 靶基因; 脂质代谢. Progress in the Study of Sterol Regulatory Element Binding Protein-1 Signal Pathway. Qiao Hui, Liu Qingping*

SREBP-1 是增加肝脏脂肪酸和甘油三酯合成的主要转录因子,本文回顾了近年来以SREBP-1相关通路为靶点NAFLD的研究进展。 Nonalcoholic fatty liver disease (NAFLD), one of the most common causes of liver injury, is cha-racterized by an increase in exogenous free fatty acids or endogenous de novogenesis in the liver, resulting in excessive accumulation of triglycerides in …

2019年3月22日 · In this work, we identified acto-myosin contractility and mechanical forces imposed by the extracellular matrix (ECM) as SREBP1 regulators. SREBP1 control by mechanical cues depends on...

SREBPs are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, …

We report the cDNA cloning of human SREBP-1, a protein that binds SRE-1, activates transcription, and thereby mediate the final regulatory step in LDL metabolism. SREBP-1 contains a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) motif, but it differs from other bHLH-ZIP proteins in its larger size (1147 amino acids) and target sequence.