
Sterol regulatory element-binding protein 1 - Wikipedia
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.
SREBP - 百度百科
Sterol-regulatory element binding proteins (SREBPs)胆固醇调节元件结合蛋白(SREBP)是位于内质网的细胞内胆固醇敏感器,通过Insig-Srebp-Scap途径对细胞内胆固醇进行反馈调节。
Sterol regulatory element-binding protein - Wikipedia
SREBP-1c is responsible for regulating the genes required for de novo lipogenesis. [6] SREBP-2 regulates the genes of cholesterol metabolism. [6] SREB proteins are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. These proteins work with asymmetric sterol regulatory element (StRE).
SREBF1 Gene - GeneCards | SRBP1 Protein | SRBP1 Antibody
2024年12月25日 · SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1) is a Protein Coding gene. Diseases associated with SREBF1 include Ifap Syndrome 2 and Mucoepithelial Dysplasia, Hereditary. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism of steroids.
Sterol regulatory element-binding protein 1(SREBP1)
SREBP1(固醇调节元件结合蛋白1)是调控脂合成的重要转录调控因子,其合成后以非活性前体的形式存在于内质网。 当固醇浓度低时,SREBP1以依赖于COPII的方式从内质网转运到高尔基体,并在高尔基体受蛋白酶加工剪切。 加工成熟后的SREBP1进入细胞核,诱导胆固醇合成和脂质稳态维持相关基因的表达。 进入细胞核的SREBP1会迅速地经历泛素化修饰,随后被蛋白酶降解。 研究表明人源异构体SREBP-1A的转录活性高于 SREBP-1C,前者能够刺激脂肪酸和胆固醇 …
该文总结了受SREBP-1调控表达的靶基 因的特点, 着重介绍了胰岛素等上游因子在SREBP-1调控过程中的作用, 为指导治疗各类代谢性疾 病提供新的思路。 关键词 SREBP-1; 胰岛素; 靶基因; 脂质代谢. Progress in the Study of Sterol Regulatory Element Binding Protein-1 Signal Pathway. Qiao Hui, Liu Qingping*
SREBP-1 是增加肝脏脂肪酸和甘油三酯合成的主要转录因子,本文回顾了近年来以SREBP-1相关通路为靶点NAFLD的研究进展。 Nonalcoholic fatty liver disease (NAFLD), one of the most common causes of liver injury, is cha-racterized by an increase in exogenous free fatty acids or endogenous de novogenesis in the liver, resulting in excessive accumulation of triglycerides in …
Sterol regulatory element binding protein 1 couples …
2019年3月22日 · In this work, we identified acto-myosin contractility and mechanical forces imposed by the extracellular matrix (ECM) as SREBP1 regulators. SREBP1 control by mechanical cues depends on...
SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
SREBPs are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, …
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that …
We report the cDNA cloning of human SREBP-1, a protein that binds SRE-1, activates transcription, and thereby mediate the final regulatory step in LDL metabolism. SREBP-1 contains a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) motif, but it differs from other bHLH-ZIP proteins in its larger size (1147 amino acids) and target sequence.