The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein (protein - RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes.

信号识别颗粒signal recognition particle （SRP）在真核生物细胞质中一种小分子RNA和六种蛋白的复合体，此复合体能识别核糖体上新生肽末端的信号顺序并与之结合，使肽合成停止，同时它又可和ER（内质网）膜上的停泊蛋白识别和结合，从而将mRNA上的核糖体，带到膜 ...

The signal recognition particle (SRP) enables cotranslational delivery of proteins for translocation into the endoplasmic reticulum (ER), but its full in vivo role remains incompletely explored. We combined rapid auxin-induced SRP degradation with proximity-specific ribosome profiling to define SRP’s in vivo function in yeast.

Signal recognition particle (SRP) receptor, also called the docking protein, is a dimer composed of 2 different subunits that are associated exclusively with the rough ER in mammalian cells. Its main function is to identify the SRP units.

2013年11月1日 · SRP delivers the nascent secretory protein together with the associated ribosome to the ER protein translocon (Sec61 complex) via the interaction with its cognate receptor (SR) an ER resident membrane protein.

SRP依赖型信号序列，也称为 信号肽，是一种短的氨基酸序列，在蛋白质合成过程中引导蛋白质进入内质网（ER）。 它具有以下功能： 引导蛋白质进入内质网： 信号肽与信号识别颗粒（SRP）结合，并引导核糖体-mRNA复合体移动到内质网膜上。 介导蛋白质穿膜： 信号肽与内质网膜上的蛋白质转运器结合，并通过转运器将蛋白质插入内质网腔或穿透内质网膜。 信号肽切割： 信号肽通常在蛋白质进入内质网腔后被信号肽酶切割，但也有部分信号肽保留在蛋白质中，并参与蛋白 …

2022年2月24日 · The emergence of an ER-targeting signal destabilized NAC’s globular domain and facilitated SRP access to the nascent chain. These findings elucidate how NAC hands over the signal sequence to SRP and imparts specificity of protein localization.

2024年6月19日 · 内质网信号肽（endoplasmic reticulum signal peptide, ER signal peptide）是一段特定的氨基酸序列，指导新合成的蛋白质从细胞质转运到内质网（ER）。 ER信号肽通常位于蛋白质的N端，通过识别和结合信号识别颗粒（signal recognition particle, SRP），介导蛋白质进入内质网腔或嵌入内质网膜。 2. **结构与特征** ER信号肽的主要特征包括： 1. **N端正电荷区**：含有1-3个正电荷氨基酸（如赖氨酸和精氨酸）。 2. **中央疏水区**：由6-15个疏水性氨基酸（ …

2018年2月9日 · The signal recognition particle (SRP) enables cotranslational delivery of proteins for translocation into the endoplasmic reticulum (ER), but its full in vivo role remains incompletely explored. We combined rapid auxin-induced SRP degradation with proximity-specific ribosome profiling to define SRP' …

2004年11月11日 · The signal recognition particle (SRP) and its membrane-bound receptor (SR) deliver membrane proteins and secretory proteins to the translocation channel in the plasma membrane (or the endoplasmic reticulum). The general outline of the SRP pathway is conserved in all three kingdoms of life.