2017年9月17日 · SS refers to the hemoglobin genotype that causes sickle cell anemia. The SS genotype consists of two sickle cell alleles (S). Each allele is inherited from each parent. The S allele shows some resistance to malaria. The S allele produces a globin chain with a …

ß-cell replacement, by pancreas or islet transplantation, is the only long-term curative option for patients with insulin-dependent diabetes. Despite good functional results, pancreas transplantation remains a major surgery with potentially …

2024年11月1日 · ß-cells are glucose sensors secreting insulin to achieve glucose homeostasis and energy storage, including lipids. In case of ß-cell failure, excessive lipid storage and obesity may lead to the development of Type-2 diabetes. The causal link between excessive body fat mass and potential degradation of ß-cells remains largely unknown and debated.

2015年9月2日 · We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional mouse pancreatic β-cells. By targeting the glucagon-like peptide-1 receptor...

2019年12月4日 · The current review discusses the role of calcium signaling in health and disease in pancreatic ?-cells and provides an in-depth look into the potential role of alterations in ?-cell Ca2+ homeostasis and signaling in the development of diabetes and highlights recent work that introduced the current theories on the connection between calcium and ...

This review describes the fundamentals and the latest advances of research on the role of fatty acids in ß-cells. This includes intracellular pathways and receptor-mediated signaling, both participating in regulated glucose-stimulated insulin secretion as well as …

It is possible that the increased glucose availability to selected brain regions induced by insulin is read as a signal to upgrade global ß‐cell function in order to defend/restore normal glucose homeostasis. In the fasting state, on the other hand, the increased brain FFA uptake restrains ß‐cell function by downgrading potentiation.

2022年9月28日 · Objective: Beside its use as a short-term marker of glycemic control, the deoxyhexose 1,5-anhydroglucitol was identified in rodents as a circulating biomarker of the functional ß-cell mass already in the asymptomatic prediabetic stage. The present study investigated the putative corresponding relevance of circulating 1,5-anhydroglucitol in ...

2014年4月15日 · Here, we investigated whether pancreatic ß-cells, like neurons, acquire and store the information contained in calcium pulses as a form of “metabolic memory”. Indeed, we find that ß-cells retain memory of prior activation, and describe the molecular mechanism that contributes to this memory.

Pancreatic β cells dedicate much of their protein translation capacity to producing insulin to maintain glucose homeostasis. In response to increased secretory demand, β cells can compensate by increasing insulin production capability even in the face of protracted peripheral insulin resistance.