Difference Between SS and SC Genotype | Definition, …
2017年9月17日 · SS refers to the hemoglobin genotype that causes sickle cell anemia. The SS genotype consists of two sickle cell alleles (S). Each allele is inherited from each parent. The S …
Generation of insulin-secreting organoids: a step toward
ß-cell replacement, by pancreas or islet transplantation, is the only long-term curative option for patients with insulin-dependent diabetes. Despite good functional results, pancreas …
Role of fatty acids in the pathogenesis of ß-cell failure and Type-2 ...
2024年11月1日 · ß-cells are glucose sensors secreting insulin to achieve glucose homeostasis and energy storage, including lipids. In case of ß-cell failure, excessive lipid storage and …
Rapid, high efficiency isolation of pancreatic ß-cells
2015年9月2日 · We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional mouse pancreatic β-cells. By targeting the glucagon-like …
Calcium Signaling in ß-cell Physiology and Pathology: A Revisit
2019年12月4日 · The current review discusses the role of calcium signaling in health and disease in pancreatic ?-cells and provides an in-depth look into the potential role of alterations in ?-cell …
Role of fatty acids in the pathogenesis of ß-cell failure and
This review describes the fundamentals and the latest advances of research on the role of fatty acids in ß-cells. This includes intracellular pathways and receptor-mediated signaling, both …
Brain substrate metabolism and ß‐cell function in humans: A …
It is possible that the increased glucose availability to selected brain regions induced by insulin is read as a signal to upgrade global ß‐cell function in order to defend/restore normal glucose …
Circulating 1,5-Anhydroglucitol as a Biomarker of ß-cell Mass ...
2022年9月28日 · Objective: Beside its use as a short-term marker of glycemic control, the deoxyhexose 1,5-anhydroglucitol was identified in rodents as a circulating biomarker of the …
Metabolic memory of ß-cells controls insulin secretion and is …
2014年4月15日 · Here, we investigated whether pancreatic ß-cells, like neurons, acquire and store the information contained in calcium pulses as a form of “metabolic memory”. Indeed, we …
The Pancreatic ß-cell Response to Secretory Demands and …
Pancreatic β cells dedicate much of their protein translation capacity to producing insulin to maintain glucose homeostasis. In response to increased secretory demand, β cells can …