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SSC缓冲液 (20X, pH7.0, 无菌)即Saline Sodium Citrate buffer，由3M NaCl以及0.3M 柠檬酸钠组成，是分子生物学中常用的核酸杂交 (Southern-blot, Northern-blot)处理溶液。 旨在用于各种杂交实验达到变性和清洗的目的。 根据使用用途不同，常用的工作浓度为2X SSC和0.5X SSC。 2X SSC缓冲液可用于高盐洗膜，洗去部分非特异性结合的探针；0.5X SSC缓冲液可用于低盐洗膜，增加核酸链的严紧性，使得RNA/DNA之间的排斥力增加。 本产品为20倍浓缩缓冲液，经过高压 …

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2020年9月25日 · Our study unveils a potential link between genetic, epigenetic, and transcriptional deregulation in CD4+ T cells of SSc patients, providing a novel integrated view of molecular components driving SSc pathogenesis.

2022年7月27日 · Systemic sclerosis (SSc) is a complex disease characterized by microvasculopathy with exaggerated response to stimuli and fibrointimal proliferation that leads to tissue ischemia, extensive fibrosis of skin and internal organs, and autoantibodies (autoAbs).

SSc is an autoimmune disease characterized by inflammation and extracellular matrix deposition that ultimately leads to loss of organ function. T cells appear to play a prominent role in its pathogenesis.

SSC缓冲液 (20X, 无菌)即Saline Sodium Citrate buffer，是分子生物学中常用的核酸杂交 (Southern-blot, Northern-blot)处理溶液。 旨在用于各种杂交实验达到变性和清洗的目的。 根据使用用途不同，常用的工作浓度为2X SSC和0.5X SSC。 2X SSC缓冲液可用于高盐洗膜，洗去部分非特异性结合的探针；0.5X SSC缓冲液可用于低盐洗膜，增加核酸链的严紧性，使得RNA/DNA之间的排斥力增加。 本产品为20倍浓缩缓冲液，经过高压湿热灭菌处理，使用时只需要用无菌 …

2020年3月9日 · New research suggests that cytotoxic T cells are dominant in the lesional skin of patients with early diffuse cutaneous systemic sclerosis (SSc) and contribute to vasculopathy and tissue...

Droplet-based single-cell transcriptome analysis of SSc skin biopsies opens avenues for dissecting patient-specific T-cell heterogeneity, providing a basis for identifying novel gene expression related to functional pathways associated with severity of SSc skin disease.

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