Objective: To report QT prolongation potential in selective serotonin reuptake inhibitors (SSRIs) in order to advise clinicians on safe use of SSRIs other than citalopram in light of citalopram …

2015年11月16日 · Selective Serotonin Reuptake Inhibitors (SSRIs): There are published case reports linking all six currently available SSRIs (fluvoxamine, fluoxetine, paroxetine, sertraline, …

QTc outcomes assessed included a prolonged QTc interval (>450 ms for men and >470 ms for women), and the mean change in QTc was adjusted for propensity score on SSRI use. SSRIs …

SSRIs were associated with a dose-dependent increase in QTc interval compared to placebo (+6.10 milliseconds; 95% CI, 3.47-8.73; P < .001). Tricyclic antidepressants (TCAs) were …

2018年3月26日 · Beach and colleagues 2 emphasize that SSRIs, including fluoxetine and paroxetine, are not statistically significantly associated with QT prolongation, as indicated by …

Post-marketing surveillance suggests that serotonin reuptake inhibitors and tricyclic antidepressants are associated with torsades de pointes (total of 662 cases) and QT …

Tricyclic Antidepressants and QTc •Tricyclic antidepressants –Affect sodium, calcium, and potassium channels –Generally are considered to be higher risk for QTc prolongation than …

We explored the clinical background of QT interval prolongation related to serotonin selective reuptake inhibitors (SSRI) use and the clinical implications of safety issues. A review was …

Aims: Selective serotonin re-uptake inhibitors (SSRIs), specifically citalopram and escitalopram, are thought to cause QTc prolongation, although studies have shown contradictory results. …

2020年11月3日 · The evidence to date suggests that citalopram (which increases QTc by about 10–20 msec) and escitalopram (which increases QTc by about 5–11 msec) carry the highest …