2024年12月25日 · SSRP1 (Structure Specific Recognition Protein 1) is a Protein Coding gene. Diseases associated with SSRP1 include Lupus Erythematosus and Systemic Lupus Erythematosus. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene expression (Transcription).

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene. [5] The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms …

2018年6月29日 · Here, using analytical ultracentrifugation (AUC) and small-angle X-ray scattering (SAXS) techniques, we characterized human SSRP1 and that from the amoeba Dictyostelium discoideum and show that both orthologs form an elongated homodimer in solution.

Our study showed that over-expression of SSRP1 reduces HR activity in response to spontaneous and HU-induced DNA damage. Depletion of SSRP1 resulted in an induction of HR as well as increased formation of H2AX and Rad51 foci.

2020年3月12日 · Here, using Xenopus laevis, we show that SSRP1 stimulates replication origin assembly on somatic chromatin by promoting eviction of histone H1 through its N-terminal domain. Histone H1 removal...

2015年12月21日 · SSRP1 is a subunit of the FACT complex, an important histone chaperone required for transcriptional regulation, DNA replication and damage repair. SSRP1 also plays important roles in...

In this study, we show that SSRP1 but not SPT16 is critical for cell survival after ionizing radiation or methyl methanesulfonate-induced single-strand DNA damage. SSRP1 is recruited to SSB in PARP-dependent manner and retained at DNA damage sites by N-terminal interactions with the DNA repair protein XRCC1.

该基因编码的蛋白质是异二聚体的一个亚基，与 SUPT16H 一起形成染色质转录延长因子 FACT。 FACT 与组蛋白 H2A/H2B 特异性相互作用以影响核小体分解和转录延伸。 事实和顺铂损伤的 DNA 可能对顺铂的抗癌机制至关重要。 这种编码的蛋白质包含一个高迁移率组框，它很可能构成顺铂修饰 DNA 的结构识别元件。 该蛋白质还充当转录激活因子 p63 的共激活因子。 已经描述了该基因的可变剪接转录变体，但其全长性质尚不清楚。 [RefSeq 提供，2008 年 7 月]

SSRP1 Is a Prognostic Biomarker Correlated with CD8(+) T Cell Infiltration in Hepatocellular Carcinoma (HCC). CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC.

2017年5月15日 · SSRP1 is recruited to SSB in a PARP-dependent manner and retained at DNA damage sites by N-terminal interactions with the DNA repair protein XRCC1. Mutational analyses showed how SSRP1 function is essential for chromatin decondensation and histone H2B exchange at sites of DNA strand breaks, which are both critical to prime chromatin for ...