
Somatostatin neurons in prefrontal cortex initiate sleep …
2023年9月21日 · Sst ChR2:Tag:SD and Sst ChR2 neurons were identified by their EYFP or mCherry signal under fluorescence illumination (LED4D, Thorlabs, coupled to a YFP or …
Excitatory SST neurons in the medial paralemniscal nucleus control ...
2022年10月19日 · To examine whether the LHA-projecting MPL SST neurons are responsible for the observed self-grooming behavior, we injected retrogradely transported AAV expressing …
Distinct roles of parvalbumin and somatostatin interneurons in …
Optical stimulation of ChR2-expressing PV (ChR2-PV) and ChR2-expressing SST (ChR2-SST) interneurons increased their firing rates (Fig. 2, C and D, left), which, in turn, decreased the …
如何用光遗传方法抑制一群神经元? - 知乎专栏
2021年4月6日 · 光遗传最经典的蛋白是channelrhodopsins (ChR2),是一种光敏感的阳离子通道,只要收到光的照射(最敏感的是大概470nm的蓝光),立马会打开然后允许Na+ K+等阳离 …
Prefrontal somatostatin interneurons encode fear memory
2019年12月16日 · We demonstrate that SST interneurons exhibit properties indicative of a memory storage substrate, including (1) learning-dependent potentiation of synaptic …
Interneuron-specific plasticity at parvalbumin and ... - Nature
2020年9月2日 · To achieve subtype-specific control of inhibitory interneurons, we selectively activated either PV or SST interneurons by expressing the light-activated cation channel …
Cell type–differential modulation of prefrontal cortical …
2020年7月22日 · For optical tagging of PV- or SST-expressing INs, we delivered Cre-inducible adeno-associated virus (AAV) carrying the gene for channelrhodopsin-2 (ChR2-mCherry) into …
Defining preBötzinger Complex Rhythm- and Pattern-Generating …
2016年8月3日 · Normal breathing in rodents requires activity of glutamatergic Dbx1-derived (Dbx1 +) preBötzinger Complex (preBötC) neurons expressing somatostatin (SST). We combined in …
Experimental approach for Channelrhodopsin-2 (ChR2)-mCherry …
... investigate whether SST interneuron activation in the VCx evokes a Ca 2+ response in astrocytes, we used an AAV-based strategy ( Figure 1 A-C) to induce the expression of the …
Somatostatin-Positive Neurons in the Rostral Zona Incerta …
2022年10月19日 · Here, we found that somatostatin (SST)-positive neurons in the rostral ZI of mice were activated by a visual innate fear stimulus. Optogenetic inhibition of SST-positive …