Dynamics of the STAT3 Transcription Factor: Nuclear Import
2011年5月19日 · STAT3 must gain entrance to the nucleus to impact transcription, however access to the nucleus is a tightly regulated process. Because nuclear trafficking is critical to …
Tracking STAT nuclear traffic - Nature Reviews Immunology
2006年8月1日 · In this Review, we focus on the signal transducer and activator of transcription (STAT) family of transcription factors. The regulation of the nuclear trafficking of STAT-family …
Regulation of Stat3 nuclear export - PMC
LMB induces nuclear accumulation of endogenous Stat3. To explore the regulation of Stat3 (St3) nuclear export, two distinct cell types and signaling pathways were examined: IL-6 stimulation …
STAT3 nuclear import is independent of tyrosine phosphorylation …
Signal transducer and activator of transcription (STAT)3 is a member of a family of DNA-binding factors that function to induce expression of responsive genes. STAT3 can act as an …
Regulation of Stat3 nuclear export - JCI
2003年2月15日 · The current study explores the regulation of Stat3 nuclear export and has identified three NES elements that control this process. Unexpectedly, two of these elements …
STAT3 nuclear import is independent of tyrosine ... - PubMed
2005年6月7日 · Signal transducer and activator of transcription (STAT)3 is a member of a family of DNA-binding factors that function to induce expression of responsive genes. STAT3 can act …
Regulation of Stat3 nuclear import by importin alpha5 and …
In this study, we investigated the mechanism for Stat3 nuclear transport. We report here that among five ubiquitously expressed human importin alphas, importin alpha5 and alpha7, but …
Dynamics of the STAT3 transcription factor: nuclear import ... - PubMed
The signal transducer and activator of transcription-3 (STAT3) induces transcription of genes that control differentiation, inflammation, proliferation, and tumor cell invasion. Cytokines such as …
lncRNA NORAD modulates STAT3/STAT1 balance and innate …
2025年1月10日 · Here we reveal an interaction between the lncRNA NORAD, noted for its role in DNA stability, and the immune related transcription factor STAT3 in embryonic and …
A STAT3 palmitoylation cycle promotes T - Nature
2020年10月7日 · Palmitoylation of STAT3 by DHHC7 promotes the membrane recruitment and phosphorylation of STAT3. APT2 promotes the nuclear translocation of p-STAT3 by selectively …