Together, these findings indicate that the dynamic interaction between mTOR and STAT5 signaling modulates the reciprocal differentiation of the effective and regulatory T cells, and differently affect their proliferation activity. This provides a new insight of …

通过瞬时转染RNAi方法，分别对AKT1和STAT5基因进行基因沉寂，检测AKT1、STAT5和mTOR在mRNA和蛋白质表达以及活性磷酸化状态变化，并进一步综述对奶牛乳腺上皮细胞β-casein合成能力的影响。

2019年8月14日 · Here, we demonstrate that liver-specific activation of mTORC1 promoted the expression of lipid synthesis genes and lead to the development of spontaneous HCC. Genetic mouse models developed...

2015年1月1日 · STAT5 and mTOR signaling events differentially regulate effector and memory Tc cell survival, and a balance between the functions of these pathways may be required for optimal immune responses [20].

2019年8月14日 · In conclusion, our data suggested that mTORC1 upregulates SREBP1 transcription via crosstalk with the STAT5 pathway which contributes to the NAFLD-related HCC pathogenesis. And the inhibitor of SREBP1 and mTOR may help to prevent HCC in clinical NAFLD patients.

In conclusion, our data suggested that mTORC1 upregulates SREBP1 transcription via crosstalk with the STAT5 pathway which contributes to the NAFLD-related HCC pathogenesis. And the inhibitor of...

2018年2月23日 · 近日有研究人员通过scid小鼠、mtor缺陷小鼠、混合嵌合体小鼠和体外菌落形成以及单核/巨噬细胞诱导试验发现，抑制mtor可导致cd11b+f4/80+细胞的数量和比例降低，以此证实mtor内源性调控单核/巨噬细胞发育。

2022年11月25日 · STAT5 controlled transcription of members of the mTOR pathway to license T cells for IL-2–mediated mTOR signaling and promoted MYC-driven metabolic changes. Together, these findings provide molecular insights downstream of IL …

2014年11月15日 · STAT5 and mTOR signaling events differentially regulate effector and memory Tc cell survival, and a balance between the functions of these pathways may be required for optimal immune responses .

2015年4月1日 · In this study, we show that there is direct interaction between mTOR and STAT5 signaling in both Tregs and Teffs: mTOR inhibition weakens Teffs growth, but make Tregs shift to STAT5/pim-2 dependent proliferation, which is more beneficial to foxp3 maintain and induction.