2024年8月12日 · SV2A PET measures are correlated with functional connectivity across brain networks, and a number of other measures of brain function, including glucose metabolism. However, the majority of studies...

2025年1月7日 · Key to visualizing nerve to muscle contact includes proper targeting of nerve fibers via neurofilament light chain (NEFL), nerve terminals via synaptic vesicle glycoprotein (SV2), and multiple nicotinic acetylcholine receptors on muscle cell surfaces (CHRN).

2019年9月18日 · The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A, SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every secretory vesicle, including synaptic vesicles, and are critical to neurotransmission.

Neuromuscular synapses can be scored for degenerative phenotypes by assessing the overlap between pre-synaptic SV2/synaptophysin and post-synaptic AChR staining, also termed NMJ ocupancy .

Hematoxylin and eosin (H&E)-stained sections from each organ showed normal histology. Forty-four human tumor specimens were also analyzed regarding their content of SV2-immunoreactive cells.

由该基因编码的蛋白质是三种相关的突触小泡蛋白之一。 编码的蛋白质可能与突触结合蛋白相互作用，以增强静止神经元中的低频神经传递。 [RefSeq 提供，2016 年 6 月] The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016]

Synaptic Vesicle Protein 2 (SV2) staining to assess muscle reinnervation. A. Using the binding of fluorescent alpha bungarotoxin (α-Btx), two motor endplates are shown (top and bottom left...

2019年8月8日 · In vertebrates, SV2s are 12-transmembrane proteins present on every secretory vesicle, including synaptic vesicles, and are critical to neurotransmission. Structural and functional studies suggest that SV2 proteins may play several roles to promote proper vesicular function.

2019年11月1日 · Synaptic Vesicle Protein 2 (SV2) is perhaps the best example of this class of protein. It is specific to vesicles that undergo calcium-regulated secretion and is the receptor for a class of anti-epileptic drugs that shows promise in the treatment of …

2024年2月8日 · SV2 family members contain twelve transmembrane helices with a large pentapeptide-repeat luminal domain (LD) and an intracellular domain with a long N-terminal disordered region. Here we present a cryo-EM structure of SV2B in a luminal-facing occluded conformation complexed with padsevonil.