Synapsin I, is the collective name for Synapsin Ia and Synapsin Ib, two nearly identical phosphoproteins that in humans are encoded by the SYN1 gene. [5][6] In its phosphorylated form, Synapsin I may also be referred to as phosphosynaspin I. Synapsin I is the first of the proteins in the synapsin family of phosphoproteins in the synaptic vesicle...

2024年12月25日 · SYN1 (Synapsin I) is a Protein Coding gene. Diseases associated with SYN1 include Intellectual Developmental Disorder, X-Linked 50 and Epilepsy, X-Linked 1, With Variable Learning Disabilities And Behavior Disorders. Among its related pathways are Neurotransmitter release cycle and Sensory processing of sound.

The SYN1 gene encodes synapsin I, a neuronal phosphoprotein associated with the membranes of small synaptic vesicles. Synapsins may play a role in synaptic neurotransmission, neuronal development, synaptogenesis, maintenance of mature synapses, and plasticity (summary by Fassio et al., 2011).

Synapsin-I (SYN1) is a presynaptic phosphoprotein crucial for synaptogenesis and synaptic plasticity. Pathogenic SYN1 variants are associated with variable X-linked neurodevelopmental disorders mainly affecting males. In this study, we expand on the ...

2025年2月8日 · This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in ...

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in ...

Enables identical protein binding activity and protein kinase binding activity. Involved in regulation of synaptic vesicle cycle and synaptic vesicle clustering. Acts upstream of or within neurotransmitter secretion.

这个基因的人类同源物涉及X连锁癫痫，伴有可变的学习障碍和行为障碍以及非综合征性X连锁智力残疾50。 与人类SYN1（突触蛋白I）正交。 [由基因组资源联盟，2022年4月提供] Dir./Indir. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gene and alternative splicing annotation with AIR.

2013年2月1日 · Our results introduce Sp1 as a fundamental activator of basal SYN1 gene expression, whose activity is modulated by the neural master regulator REST and CpG methylation. Background: Syn I plays a key role at presynaptic terminals. Results: Sp1 binds to the SYN1 promoter, activating its transcription.

Synapsin 1 is a peripheral membrane protein on synaptic vesicles that mediates vesicle binding to the cytoskeleton. Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly …