ROS-responsive core–shell microgels for phase-specific treatment …
2025年3月1日 · In this study, SaB/Cand@C-S MGs were introduced. The shell composed of HBPAK scavenges ROS, restoring mitochondrial function and disrupting harmful ROS-induced …
Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of
2024年3月15日 · We discuss here the mechanism and modulators of the JNK-SAB-ROS activation loop, which is the core component of mitochondria-dependent cell death, specifically …
An anti-ROS/hepatic fibrosis drug delivery system based on …
2010年10月1日 · Salvianolic acid B (SAB) is a major water-soluble polyphenolic acid extracted from Radix Salviae miltiorrhizae (Sm), which is a common herbal medicine that has been …
trans-Fatty acids facilitate DNA damage-induced apoptosis …
Therapeutic effectiveness of tag-Sab KIM1 has been demonstrated in various in vitro and in vivo disease models associated with the mitochondrial JNK-Sab-ROS axis 74, implicating its …
Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell …
2024年3月14日 · We discuss here the mechanism and modulators of the JNK-SAB-ROS activation loop, which is the core component of mitochondria-dependent cell death, specifically …
反式脂肪酸通过线粒体JNK-Sab-ROS阳性反馈回路促进DNA损伤诱 …
EA的促凋亡作用可通过击倒Sab（一种位于线粒体外膜的c-Jun N端激酶（JNK）相互作用蛋白）来阻断，介导线粒体活性氧（ROS）生成和JNK激活的相互放大。 EA增强了阿霉素诱导的线粒 …
trans-Fatty acids facilitate DNA damage-induced apoptosis
2020年2月17日 · These results demonstrate that in response to DNA damage, TFAs drive the mitochondrial JNK-Sab-ROS positive feedback loop and ultimately apoptosis, which may …
这所院校又添新作：线粒体 P-JNK 靶标 SAB （SH3BP5） 调节细胞 …
2024年1月1日 · 一篇最新的论文发现了JNKs和线粒体蛋白SAB相互作用，参与了细胞死亡过程的信号调节。 这一发现使我们更好地理解了细胞死亡的机制和持续激活JNK（P-JNK）的过程。 …
Salvianolic Acid B Inhibits Ferroptosis and Apoptosis during
2023年5月16日 · Myocardial ischemia/reperfusion injury (MIRI) is related to ferroptosis and apoptosis elicited by reactive oxygen species (ROS). In this research, we investigated the …
JNK interaction with Sab mediates ER stress induced inhibition of ...
2014年1月9日 · JNK interacts with Sab, which leads to the inhibition of respiration and ROS production, the latter amplified by calcium release from ER, creating a self-amplification cycle …