Investigations of genes important in liver cancers have focused on Sal-like protein 4, SALL4, a member of a family of zinc finger transcription factors. It is a regulator of embryogenesis, …

SALL4 is a novel therapeutic target for liver cancers. SALL4's expression is an indicator of stem cells, a prognostic marker in liver cancers, correlates with cell and tumor growth, with …

2013年6月13日 · SALL4 is an oncofetal protein that is expressed in the human fetal liver and silenced in the adult liver, but it is reexpressed in a subgroup of patients who have …

2013年6月25日 · SALL4 is expressed in human foetal liver, but not in the healthy adult liver. However, SALL4 is re-expressed in a number of cancers, including acute myeloid leukaemia …

2016年3月3日 · Sal-like protein 4 (SALL4) is a newly discovered proto-oncogene that is expressed in embryonic stem cells and liver stem cells but is not expressed in normal adult …

Their upregulation is linked to tumor differentiation, TNM stage, tumor size, vascular invasion, and liver cirrhosis in HCC patients. This SALL4/Wnt/β‐catenin signaling may aid in the early …

In the liver, SALL4 elevated was expressed in fetal liver and was silenced in mature hepatocytes. Some researchers have found that SALL4 was reexpressed and associated with the poorest …

2015年2月1日 · The expression levels of SALL4 gradually fall during liver development. SALL4 overexpression enhances while SALL4 knockdown impairs induced differentiation of …

2013年6月13日 · SALL4 is a marker for a progenitor subclass of hepatocellular carcinoma with an aggressive phenotype. The absence of SALL4 expression in the healthy adult liver enhances …

Aims: SALL4 is a marker of germ cell tumours. The aim of this study was to investigate SALL4 expression in blastemal tumours, particularly in hepatoblastoma. Methods and results: The …

2015年9月9日 · Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC). In our study, 175 ICC cases with an …

SALL4 is expressed in human foetal liver, but not in the healthy adult liver. However, SALL4 is re-expressed in a number of cancers, including acute myeloid leukaemia and some liver,...

Sall4 has been shown to be among the regulators of organogenesis, embryogenesis, maintenance of pluripotency, and early embryonic cell fate decisions in embryonic stem cells. …

2012年11月23日 · Investigations of genes important in liver cancers have focused on Sal-like protein 4 (SALL4), a member of a family of zinc finger transcription factors. It is a regulator of …

2014年4月17日 · Some researchers have verified that SALL4, a protein expressed in fetal, but not adult, liver cells, was reexpressed in liver tissues of a subgroup of adult hepatocellular …

2009年3月1日 · In this study, we have identified for the first time the expression and functional role of Sall4 during liver development. The appearance at E13.5–14.5 of hepatoblasts around …

Liver cancer: SALL4--a cancer marker and target. Liver cancer: SALL4--a cancer marker and target. Liver cancer: SALL4--a cancer marker and target Nat Rev Clin Oncol. 2013 …

2019年12月1日 · SALL4 activates the transcription of genes that regulate oxidative phosphorylation to increase oxygen consumption, mitochondrial membrane potential, and ATP …

SALL4 is a protein made by germ cells and by tumors that arise from germ cells, including seminoma, embryonal carcinoma, and yolk sac tumor. ... Additionally, some non-germ cell …

SALL4 activates the transcription of genes that regulate oxidative phosphorylation to increase oxygen consumption, mitochondrial membrane potential, and ATP generation in cancer cells. …