SAV1 Gene - GeneCards | SAV1 Protein | SAV1 Antibody
2024年12月25日 · SAV1 (Salvador Family WW Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with SAV1 include Microphthalmia, Syndromic 10 and …
SAV1 - Wikipedia
Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. [ 5 ] [ 6 ] [ 7 ] WW domain -containing proteins are found in all eukaryotes and play an important role in the …
经典信号通路总结——Hippo信号通路 - 知乎 - 知乎专栏
在3T3-L1细胞中, SAV1表达会稳定PPARγ蛋白水平, 而SAV1敲低会导致PPARγ水平降低。SAV1与PPARγ结合可能阻断了PPARγ被泛素化通路元件接近, 并阻止蛋白酶体对PPARγ的降解。 事 …
Correction of the tumor suppressor Salvador homolog-1 ... - Nature
2020年5月21日 · Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in …
含萨尔瓦多家族 WW 结构域的蛋白 1（SAV1）基因 | MCE
该基因编码的蛋白质具有两个 WW 结构域、一个 SARAH 结构域和一个卷曲螺旋区域，在成人组织中普遍表达。 该蛋白与 MST1 (哺乳动物不育 20 样激酶 1) 结合并促进 MST1 诱导的细胞凋亡 …
SAV1 salvador family WW domain containing protein 1 [ (human)]
2025年2月8日 · SAV1 suppresses tumor growth in colorectal cancer and is regulated by miR-21. These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points …
Hippo 信号通路 (Hippo pathway) - Abcam中文官网
这些激酶与衔接蛋白 salvador 同系物 1（SAV1）形成的复合物可以磷酸化并激活效应蛋白，即大肿瘤抑制因子 1/2（LATS1/2）。MAP4K 和 TAOK 激酶也可以共同使 LATS1/2 磷酸化 3 。
Whole-exome sequencing reveals genomic landscape of
2024年11月17日 · Biofunctional investigations reveal a tumor-suppressor role of SAV1: its inactivation suppresses Hippo signaling, leading to YAP activation, thereby promoting tumor …
SAV1 (D6M6X) Rabbit mAb #13301 - Cell Signaling Technology …
SAV1 (D6M6X) Rabbit mAb recognizes endogenous levels of total SAV1 protein. Human, Mouse. Monoclonal antibody is produced by immunizing animals with a synthetic peptide …
SAV1在肿瘤中作用的研究进展-期刊-万方数据知识服务平台
2020年4月10日 · SAV1是哺乳动物Hippo信号通路的核心激酶之一,主要参与调节细胞增殖与器官发育.近期研究发现,在众多肿瘤组织中SAV1均处于低表达或者缺失状态,SAV1敲除的小鼠模型更 …