2024年12月25日 · SAV1 (Salvador Family WW Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with SAV1 include Microphthalmia, Syndromic 10 and Hepatocellular Clear Cell Carcinoma . Among its related pathways are Hippo-Merlin signaling dysregulation and Pleural mesothelioma .

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. [ 5 ] [ 6 ] [ 7 ] WW domain -containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation , transcription , …

在3T3-L1细胞中, SAV1表达会稳定PPARγ蛋白水平, 而SAV1敲低会导致PPARγ水平降低。SAV1与PPARγ结合可能阻断了PPARγ被泛素化通路元件接近, 并阻止蛋白酶体对PPARγ的降解。 事实上, SAV1可能也与TAZ竞争结合PPARγ, 因为这两个蛋白结合在同一个PPXY模体上。由于MST1/2与SAV1刺激LATS1/2的活性, 它们还可能通过促进TAZ磷酸化使其定位于细胞质, 间接影响TAZ与PPARγ在细胞核中结合。 SAV1是否通过调控TAZ发挥功能目前还不清楚, 但它在脂肪形成过 …

2020年5月21日 · Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in several cancer types....

该基因编码的蛋白质具有两个 WW 结构域、一个 SARAH 结构域和一个卷曲螺旋区域，在成人组织中普遍表达。 该蛋白与 MST1 (哺乳动物不育 20 样激酶 1) 结合并促进 MST1 诱导的细胞凋亡。 它也被证明可以与 HAX1 (造血细胞特异性蛋白 1 (HS1) 相关蛋白 X-1) 结合并减弱 HAX1 的抗凋亡作用。 对人类和小鼠的研究表明，该基因具有肿瘤抑制因子的作用。 [RefSeq 提供，2012 年 8 月]

2025年2月8日 · SAV1 suppresses tumor growth in colorectal cancer and is regulated by miR-21. These results suggest Salvador enhances the effects of Hippo kinase activity at multiple points in the Hippo pathway. Here, the authors discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2 activation.

这些激酶与衔接蛋白 salvador 同系物 1（SAV1）形成的复合物可以磷酸化并激活效应蛋白，即大肿瘤抑制因子 1/2（LATS1/2）。MAP4K 和 TAOK 激酶也可以共同使 LATS1/2 磷酸化 3 。

2024年11月17日 · Biofunctional investigations reveal a tumor-suppressor role of SAV1: its inactivation suppresses Hippo signaling, leading to YAP activation, thereby promoting tumor growth and metastasis. Collectively, our results delineate the genomic landscape of Chinese ICCs and identify SAV1 as a potential driver of ICC.

SAV1 (D6M6X) Rabbit mAb recognizes endogenous levels of total SAV1 protein. Human, Mouse. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SAV1 protein.

2020年4月10日 · SAV1是哺乳动物Hippo信号通路的核心激酶之一,主要参与调节细胞增殖与器官发育.近期研究发现,在众多肿瘤组织中SAV1均处于低表达或者缺失状态,SAV1敲除的小鼠模型更是能诱导出各种肿瘤的发生,表明SAV1的缺失与肿瘤的发生之间存在着直接或间接的分子机制.全文就近年有关SAV1在不同肿瘤中的研究进展进行系统综述,以期为发现新的肿瘤治疗靶点提供理论依据.