All three known members of the selectin family (L-, E-, and P-selectin) share a similar cassette structure: an N-terminal, calcium-dependent lectin domain, an epidermal growth factor (EGF)-like domain, a variable number of consensus repeat units (2, 6, and 9 for L-, E-, and P-selectin, respectively), a transmembrane domain (TM) and an ...

L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in the human by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant. [ 5 ]

Selectins are a family of cell surface lectins that mediate leucocyte-endothelial cell interactions in inflammatory and immune reactions by binding sialylated, fucosylated, and sometimes sulphated carbohydrate ligands. 304–306 The selectin family consists of three closely related proteins—L-selectin, E-selectin, and P-selectin, all having a ...

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. Leucocytes express L-selectin, activated platelets express P-selectin, ...

Selectin-binding to P-selectin glycoprotein ligand-1 (PSGL-1) on the neutrophil surface, elicits a specific intracellular signaling pathway resulting in affinity activation of lymphocyte-function-associated antigen-1 (LFA-1).

From C-terminus to N-terminus, the selectins are composed of a relatively short cytoplasmic domain, a single transmembrane domain, a series of CR (consensus repeat) or structural domains (from 2 in L-selectin to 9 in P-selectin), an EGF (epidermal growth factor) -like domain, and a lectin-like domain.

2023年7月19日 · L-selectin is the smallest of the selectins and is expressed on all granulocytes and monocytes and the majority of lymphocytes. P-selectin is the largest selectin and is found on the...

L‐selectin is a cell adhesion molecule consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. It is expressed on most leukocytes and is involved in their rolling on ...

Cell adhesion molecules play a key role in different physiological and pathological phenomena. Selectins comprise a family of three members (E-, P-, and L-selectin) that are differentially expressed by leukocytes and endothelial cells, and are involved in the early steps of leukocyte extravasation. …

The selectin family of adhesion molecules mediates the initial attachment of leukocytes to venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury and inflammation.