P-SELECTIN EXPRESSION MARKS ACTIVE AND MYELOID-BIASED HEMATOPOIETIC ...
2019年8月1日 · Selp preferentially marks CD150high Lin-Sca-1+ckit+CD48- HSCs, which are myeloid-biased. Beyond an increase of the expression levels of Selp by aged HSCs, the …
Depleting myeloid-biased haematopoietic stem cells rejuvenates …
2024年3月27日 · Here we demonstrate that antibody-mediated depletion of my-HSCs in aged mice restores characteristic features of a more youthful immune system, including increasing …
Reducing functionally defective old HSCs alleviates aging-related ...
2025年1月2日 · Single-cell sequencing (scRNA-seq) reveals an increased aging heterogeneity in old HSCs. Systematic molecular and functional characterization indicate the presence of …
A comprehensive transcriptome signature of murine hematopoietic …
2021年8月12日 · We show that Selp (P-selectin), the most consistent deregulated gene, is not merely a marker for aged HSCs but is associated with HSC functional decline. Additionally, …
Hematopoietic stem cell aging and leukemia transformation
2023年8月10日 · Selp expression at the transcriptional and protein levels in old HSCs has been found to contribute to myeloid-biased hematopoiesis and HSC activation phenotypes. 38 In a …
2002 – P-SELECTIN CONTRIBUTES TO HEMATOPOIETIC STEM
2023年1月1日 · In this study we identify Selp is not only a marker but also an important regulator of hematopoiesis and HSC aging. We highlight a key role for pro-inflammatory cytokine …
Selp在血液系统中的功能及机制研究-学位-万方数据知识服务平台
本研究利用CRISPR/Cas9技术构建了Selp及Selplg全身性敲除鼠，将其作为工具，对Selp及Selplg在维持HSC稳态和调控HSC功能中的作用进行深入探究。 同时我们还利用BCR-ABL1诱 …
Cell子刊：同济大学岳锐团队实现衰老造血干细胞的年轻化 - 知乎
研究者还分析了年老（24月龄）HSC的年轻化效果，并利用 单细胞RNA测序 （scRNA-seq）和移植实验对3D共培养后的淋系祖细胞（CLP）和HSC进行了深入分析， 从而证明3D共培养可以 …
Hematopoietic Stem Cell Aging: Wrinkles In Stem Cell Potential
2007年8月21日 · SelP expression on HSC is consistent with exposure of HSC to a highly inflammatory environment, because several studies have identified the major role of SelP in …
Platelet-derived circulating soluble P-selectin is sufficient to induce ...
2023年10月20日 · sP-sel was identified as a novel endogenous HSC-mobilizing agent. sP-sel injections achieved a relatively faster and more convenient regimen to mobilize HSCs in mice …