2024年12月25日 · SEMA3F (Semaphorin 3F) is a Protein Coding gene. Diseases associated with SEMA3F include Myasthenic Syndrome, Congenital, 3B, Fast-Channel and Neuroma . Gene Ontology (GO) annotations related to this gene include signaling receptor activity and chemorepellent activity .

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene. [5] [6] [7] The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et …

SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer progression, hence serving as a prognostic biomarker and an attractive target for therapeutic intervention to halt metastasis.

SEMA3F is a prognostic marker in Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma

2024年9月4日 · In summary, SEMA3F emerges as an independent predictor for a favorable prognosis in patients with early-stage esophageal adenocarcinoma. Additionally, NRP2 expression is linked to a higher risk...

2025年2月8日 · Sema3F functions as an unconventional Sema3 that promotes extraembryonic angiogenesis by inhibiting the Myc-regulated synthesis of Thbs1 in visceral yolk sac epithelial cells.

2025年3月1日 · Sema3F can regulate neuronal migration, growth cone collapse, spine pruning, axon guidance, synapse plasticity, circuit connectivity in neurons. Besides, Sema3F functions as a chemotactic molecule to mediate OPCs recruitment and remyelination.

Class-3 semaphorins constitute a subfamily of seven vertebrate semaphorins which differ from the other vertebrate semaphorins in that they are the only secreted semaphorins and are distinguished from other semaphorins by the presence of a basic domain at their C termini.

2018年11月23日 · Semaphorin 3F (SEMA3F), a member of the class 3 semaphorins, was initially identified as an axon guidance factor, that repels axons and collapses growth cones. However, SEMA3F has similar effects on endothelial cells (ECs) and tumor cells.

Several class 3 semaphorins, including semaphorin 3F (Sema3F) bind to the receptor neuropilin-2 to confer chemorepulsive responses in vitro. To understand the role of Sema3F in the establishment of neural circuitry in vivo, we have generated sema3F null …