最广泛使用的脓毒症模型是盲肠结扎和穿刺 (CLP) 模型，该模型被认为与人类脓毒症具有显着的相容性。 CLP 模型的主要优点是腹膜通过与失活组织结合而接种了来自动物本身的混合微生物菌群。

2024年5月15日 · Here, we demonstrate the utility of CD5L for treating experimental sepsis caused by cecal ligation and puncture (CLP). We show that CD5L’s important features include its ability to...

Based on the understanding of molecular mechanisms underlying sepsis, new clinical therapies have been designed to neutralize several key molecules involved in the initiation and progression of sepsis, including lipopolysaccharide (LPS), a core component of G - …

2011年5月7日 · The most widely used clinical model is cecal ligation and puncture (CLP). The CLP model consists of the perforation of the cecum allowing the release of fecal material into the peritoneal cavity to generate an exacerbated immune response induced by polymicrobial infection. This model fulfills the human condition that is clinically relevant.

Polymicrobial sepsis induced by cecal ligation and puncture (CLP) is the most frequently used model because it closely resembles the progression and characteristics of human sepsis. Here we summarize the role of several immune components in the pathogenesis of …

2008年12月11日 · In this protocol, we define standardized procedures to induce acute sepsis in mice and rats by CLP, and we characterize distinct locations for cecal ligation that correlate with predictable...

2019年11月7日 · Our results illustrate the susceptibility of three different organs toward organ damage in CLP-induced sepsis, namely liver, gut, and endothelium. During SIRS and sepsis, these organs are indeed known to be vulnerable for increased damage, eventually resulting in multiple organ failure.

To investigate the complex molecular mechanisms of sepsis, various animal models have been developed, the most frequently used being the cecal ligation and puncture (CLP) model in rodents.

2025年1月1日 · The CLP model is the gold standard for inducing sepsis as it may result in severe peritonitis and a failure of several organs because it closely mimics the pathological signs of sepsis in clinical settings [55].

Methods used to establish sepsis models by host-barrier sabotaging include cecal ligation/puncture (CLP), colon ascendens stent plantation (CASP), and feces intraperitoneal-injection (FIP). The CLP model was accepted as a typical model of sepsis, as it closely replicates the pathology and physiology of human sepsis [5, 6].