Borrelia burgdorferi serine protease HtrA is a pleiotropic regulator …
2025年3月1日 · High-temperature requirement protease A (HtrA) is a family of serine proteases that regulate bacterial stress response through controlling protein quality. This report shows …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable - Nature
2010年8月24日 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and …
Phospho-tau serine-262 and serine-356 as biomarkers of pre …
2025年2月10日 · 36,37) and at serine-262 and serine-356 jointly 38, as well as by BR serine/threonine kinase 2 (BRSK2) at serine-262 (refs. 39 , 40 ). Protein kinase A was …
Serine and one-carbon metabolism in cancer - Nature
2016年9月16日 · Serine is a non-essential amino acid that can be taken up by the cell or synthesized de novo from glycolytic intermediates through the serine synthesis pathway …
Revisiting the role of serine metabolism in hepatic lipogenesis
2023年5月11日 · Third, serine supplementation has been shown to attenuate HS in rodent models fed with high-fat diet or ethanol 10,11,12, and in a proof-of-concept human study 8, in which …
The ins and outs of serine and glycine metabolism in cancer
2021年1月28日 · Serine and glycine synthesis (Fig. 1) consists of two processes: de novo serine synthesis from glucose and reversible interconversion of serine into glycine. De novo serine …
The impact of physiological metabolite levels on serine uptake ...
2021年10月26日 · Serine is a non-essential amino acid that is critical for tumour proliferation and depletion of circulating serine results in reduced tumour growth and increased survival in …
Cellular redox state constrains serine synthesis and nucleotide ...
2019年9月16日 · Serine deprivation has been shown to enhance the antiproliferative effects of the biguanides phenformin and metformin 15, both of which inhibit complex I of the mitochondrial …
Serine synthesis through PHGDH coordinates nucleotide levels by ...
2018年12月21日 · The serine, glycine, one-carbon network generates carbon units that satisfy many metabolic demands including nucleotide precursors for anabolic metabolism, redox …
Functional profiling of serine, threonine and tyrosine sites
2024年9月23日 · The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible …