2024年12月25日 · SERPINE2 (Serpin Family E Member 2) is a Protein Coding gene. Diseases associated with SERPINE2 include Ciliary Dyskinesia, Primary, 30 and Ciliary Dyskinesia, Primary, 27. Among its related pathways are Diseases of hemostasis and Response to elevated platelet cytosolic Ca2+.

2023年1月16日 · SERPINE2 knockdown markedly suppressed RCC cell growth and invasion, while SERPINE2 overexpression dramatically promoted RCC cell metastasis both in vitro and in vivo.

SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis. Bone morphogenetic protein 2 upregulates SERPINE2 expression through noncanonical SMAD2/3 and p38 MAPK signaling pathways in human granulosa-lutein cells.

2016年11月23日 · In this study, serpinE2/protease nexin-1 was over-expressed in a cardiac fibrosis model induced by pressure-overloaded via transverse aortic constriction (TAC) in mouse. Knockdown of serpinE2...

2012年3月15日 · Serine protease inhibitors, termed serpins, are key regulators in many biologic events. Protease nexin-1 (PN-1) is a serpin that is barely detectable in plasma but found in many organs and produced by most cell types, including monocytes, platelets, and vascular cells.

SERPINE2, also known as protease nexin I, is a 44 kDa glycoprotein. The main physiological role of SERPINE2 is to facilitate coagulation and fibrinolysis. SERPINE2 inhibits trypsin-like serine proteases, trypsin, thrombin, urokinase and plasmin but does not inhibit NE nor chymotrypsin-like proteases [ 161 , 162 ].

2025年2月8日 · SERPINE2 is a major plasminogen activator (PA) inhibitor in the placenta and uterus during the estrous cycle, pregnancy, and lactation. It may participate in the PA-modulated tissue remodeling process in the mouse placenta and uterus.

Serine proteinase inhibitor, clade E, member 2 (SERPINE2), is a cell- and extracellular matrix-associated inhibitor of thrombin. Although SERPINE2 is a candidate susceptibility gene for chronic obstructive pulmonary disease, the physiologic role of this protease inhibitor in …

SERPINE2 is epigenetically modulated by METTL3. (A) Prediction of a putative m6A methylation site in SERPINE2 mRNA (SRAMP tool). (B) Prediction of the binding of METTL3 and SERPINE2 mRNA (RBPsuite web). (C) Relative expression of SERPINE2 mRNA (qPCR) in NUGC-4 and SNU-668 cells transfected with sh-METTL3 or sh-NC. (D) SERPINE2 protein ...

2024年3月5日 · Title: SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis. Bone morphogenetic protein 2 upregulates SERPINE2 expression through noncanonical SMAD2/3 and p38 MAPK signaling …