2022年11月10日 · Mechanically, we found that LINC02820 may affect the cytoskeletal remodeling, interact with splice factor 3B subunit 3 (SF3B3), and cooperate with TNFα to amplify the NF-κB signaling pathway,...

2022年11月10日 · Considering SF3B3 is a subunit of U2, a small nuclear ribosomal protein, and is involved in the alternative splicing of RNA. Taken together, we conclude that LINC02820 may function by interacting directly with SF3B3 and contribute to metastasis in ESCC by regulating the NF-κB signaling pathway (Fig. (Fig.8H 8H).

Mechanically, we found that LINC02820 may affect the cytoskeletal remodeling, interact with splice factor 3B subunit 3 (SF3B3), and cooperate with TNFα to amplify the NF-κB signaling pathway, which can lead to ESCC metastasis.

Mechanically, we found that LINC02820 may affect the cytoskeletal remodeling, interact with splice factor 3B subunit 3 (SF3B3), and cooperate with TNFα to amplify the NF-κB signaling pathway ...

As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its …

Studies have shown that SF3B1, SF3B2, and SF3B3 can regulate target gene expression by alternative splicing to promote cancer progression (Chen et al., 2017), also SF3B3 controls AS in renal ...

该基因编码剪接因子 3b 蛋白复合物的第 3 亚基。 剪接因子 3b 与剪接因子 3a 和一个 12S RNA 单元一起形成 U2 小核糖核蛋白复合物 (U2 snRNP) 。 剪接因子 3b/3a 复合物以序列独立的方式结合内含子分支位点上游的前体 mRNA，并可能将 U2 snRNP 锚定到前体 mRNA。 剪接因子 3b 也是较小的 U12 型剪接体的一个组成部分。 亚基 3 也被确定为 STAGA (SPT3-TAF (II) 31-GCN5L 乙酰化酶) 转录共激活因子-HAT (组蛋白乙酰转移酶) 复合物和 TFTC (无 TATA 结合蛋白的 TAF …

Gain- and loss-of-function experiments demonstrate that nuclear AGO3 interacts directly with SF3B3, a component of the U2 spliceosome complex, to aid global mRNA splicing, and in particular the isoforms of the gene , resulting in a dysregulated Nisch isoform ratio.

Plasmid SF3B3 from Dr. Eugene Yeo's lab contains the insert SF3B3 and is published in Nat Struct Mol Biol. 2020 Oct;27 (10):989-1000. doi: 10.1038/s41594-020-0477-6. Epub 2020 Aug 17. This plasmid is available through Addgene.

Expression levels of SF3B1 and SF3B3 and their prognostic value were validated in large cohorts using publicly available gene expression data sets including The Cancer Genome Atlas. SF3B1 and SF3B3 levels were significantly increased in ERα-positive cells with acquired tamoxifen (MCF-7/LCC2; both P<0.0002) and fulvestrant/tamoxifen resistance ...