Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption.

SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional units of the kidney), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa.

2023年6月3日 · SGLT-2 are proteins expressed in the proximal convoluted tubules of the kidneys that exert their physiologic function by reabsorbing filtered glucose from the tubular lumen. All four SGLT-2 inhibitors reduce the reabsorption of filtered glucose, decrease the renal threshold for glucose (RTG), and promote urinary glucose excretion.

The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene. [5] SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins.

2023年5月30日 · SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins. SGLT-2 inhibitors inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood.

2023年3月16日 · SGLT2 inhibitors are a type of medicine you might take to lower your blood sugar when you have type 2 diabetes. They increase the amount of blood sugar (or glucose) you get rid of when you pee....

SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. Medicines in the SGLT2 inhibitor...

2024年12月6日 · SGLT2 inhibitors are a type of oral (taken by mouth) prescription medicine commonly recommended for people with chronic kidney disease (CKD). They help keep your glomeruli (small filters in your kidneys) healthy and lower your urine albumin-creatinine ratio (uACR) level (a marker of kidney damage).

Sodium-glucose co-transporter-2 inhibitors, often called SGLT2 inhibitors, are used to manage blood sugar levels. They can be taken on their own or with other diabetes medications such as metformin, sulphonylureas or insulin. How do SGLT2 inhibitors work?

2024年9月10日 · Glucose transporters SGLTs (sodium-dependent glucose transporters) are one of the three identified families of glucose transporters in humans. Being a large molecule glucose requires assistance from membrane transporters to cross the …