
SHMT2 Gene - GeneCards | GLYM Protein | GLYM Antibody
2024年12月25日 · SHMT2 (Serine Hydroxymethyltransferase 2) is a Protein Coding gene. Diseases associated with SHMT2 include Neurodevelopmental Disorder With Cardiomyopathy, Spasticity, And Brain Abnormalities and Periventricular Heterotopia …
The serine hydroxymethyltransferase-2 (SHMT2) initiates ... - Nature
2020年6月22日 · Serine hydroxymethyltransferase-2 (SHMT2) is a key mitochondrial enzyme in serine catabolism that converts serine to glycine and a one-carbon unit that yields S -adenosyl methionine (SAM) and...
SHMT2 serine hydroxymethyltransferase 2 [ (human)]
serine hydroxymethyltransferase 2 (SHMT2) is acetylated at K95 in colorectal cancer (CRC) cells. SHMT2-K95-Ac disrupts its functional tetramer structure and inhibits its enzymatic activity. SHMT2-K95-Ac promotes its degradation via the K63-ubiquitin-lysosome pathway in a glucose-dependent manner.
SHMT2 promotes papillary thyroid cancer metastasis through …
2024年1月25日 · Here, we reveal that serine hydroxymethyltransferase-2 (SHMT2) generates S-adenosylmethionine (SAM) to epigenetically repress phosphatase and tensin homolog (PTEN), leading to papillary thyroid...
SHMT2 promotes cell viability and inhibits ROS-dependent
Mitochondrial serine hydroxymethyltransferase (SHMT2) catalyzes the conversion of serine to glycine and concomitantly produces one-carbon units to support cell growth and is upregulated in various cancer cells.
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial ...
SHMT2 catalyzes the first step in mitochondrial one-carbon metabolism, which, particularly in proliferating cells, produces tetrahydrofolate (THF)-conjugated one-carbon units used in cytoplasmic reactions despite the presence of a parallel cytoplasmic pathway.
SHMT2 promotes cell viability and inhibits ROS-dependent
2022年4月14日 · Blocking ROS production by formate and antioxidants effectively rescued cell apoptosis via the intrinsic signaling pathway. Our findings contribute to the paradigm that SHMT2 is critical to the...
Serine hydroxymethyltransferase 2 (SHMT2) potentiates the …
Serine hydroxymethyltransferase 2 (SHMT2) was identified to be upregulated in OSCC and its high expression was associated with poor patient prognosis. This paper set out to assess the influence of SHMT2 on OSCC progression and the potential mechanisms related to interleukin enhancer-binding factor 2 (ILF2).
Serine hydroxymethyltransferase 2: a novel target for human …
SHMT2 is a PLP-dependent tetrameric enzyme that catalyzes the reversible transition from serine to glycine, thus promoting the production of one-carbon units that are indispensable for cell growth and regulation of the redox and epigenetic states of cells.
SHMT2-mediated mitochondrial serine metabolism drives 5-FU …
Importantly, regardless of the serine feeder strategy, serine hydroxymethyltransferase-2 (SHMT2)-driven compartmentalization of one-carbon metabolism inside the mitochondria represents a specific adaptation of resistant cells to support purine biosynthesis and potentiate DNA damage response.
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