2024年12月25日 · SIAH1 (Siah E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with SIAH1 include Buratti-Harel Syndrome and Non-Specific Syndromic …

E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene. [5][6] This gene encodes for a polypeptide structure that is a member of the seven in absentia …

SIAH1 has been identified as a putative tumor suppressor gene for human hepatocellular carcinomas, with a correlation between its suppressed expression and tumor size and …

该基因编码的蛋白质是七缺席同源物 (SIAH) 家族的成员。 该蛋白质是一种 E3 连接酶，参与泛素化和蛋白酶体介导的特定蛋白质降解。 这种泛素连接酶的活性与某些形式的帕金森病的发展 …

SIAH1 could interact with TRB3 both in vitro and in vivo. Importantly, SIAH1 targeted TRB3 for proteasome-dependent degradation. Cotransfection of SIAH1 could withdraw up-regulation of …

2022年10月1日 · Seven in absentia homolog 1 (Siah1) has been shown plays important roles in the pathogenesis and development of multiple cancers. However, the functions and …

2021年6月10日 · SIAH1 was found to encode a 282-amino acid protein with 76% amino acid identity to the Drosophila sina protein. By PCR of a lymph node cDNA library, Mei et al. (2007) …

2014年9月9日 · Two SINA homologs have been identified in the human genome, Siah1 and Siah2 [2], both of which encode functional proteins. The Siah family of proteins are evolutionarily …

2024年10月28日 · Two high-resolution structures of the human E3 ubiquitin ligase Siah1. SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of …

2019年10月18日 · Here we show Siah1 as an ubiquitin ligase that preferentially interacts with Akt3 and facilitates ubiquitination and degradation of Akt3. Akt3 is enriched in the axonal shaft …