2024年12月25日 · SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5) is a Protein Coding gene. Diseases associated with SIGLEC5 include Congenital Disorder Of Glycosylation, Type Iic. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

In this study, we found that Siglec-5, a member of the CD33rSiglecs, is expressed by most activated T cells upon antigen receptor stimulation. Functionally, Siglec-5 suppresses T cell activation. In support of these findings, we found that Siglec-5 overexpression abrogates antigen receptor induced activation of NFAT and AP-1.

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. [3] [4] SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

2023年3月8日 · Siglec-5/10在T细胞急性激活后上调，能够影响抗肿瘤免疫。 Siglec-9在癌症患者和血液和肿瘤浸润T细胞上表达升高，尤其是终末期PD-1+Tex细胞上高表达，减少细胞上Siglec-9的配体能够显著增强T细胞效应功能和肿瘤杀伤。 靶向Siglec基本是两个方向：肿瘤细胞和免疫细胞。 Siglec起初是在人类B细胞上被发现（Siglec-2），以肿瘤细胞上Siglec受体作为抗原是最初的靶点。 之后发现将Siglec-3作为AML细胞靶点，开发并进行了ADC药物试验。 最近的一项目 …

Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome. Plasma Siglec-5 levels are implicated as an early diagnostic marker of CLI in T2DM patients and it may become a target for the prevention or treatment of CLI in diabetes.

Siglecs are sialic-acid-binding immunoglobulin-like lectins that are mostly expressed by cells of the immune system. Siglecs can be divided into two subsets based on their sequence similarity and...

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

该基因编码唾液酸结合免疫球蛋白样凝集素 (Siglec) 家族的成员。 这些细胞表面凝集素的特征在于免疫球蛋白 (Ig) 样结构域中的结构基序和第一个 Ig V 组结构域中的唾液酸识别位点。 所编码的蛋白质是 Siglecs CD33 相关子集的成员，可抑制多种细胞类型的激活，包括单核细胞、巨噬细胞和中性粒细胞。 B 族链球菌 (GBS) 与编码蛋白的结合在 GBS 免疫逃避中发挥作用。 [RefSeq 提供，2012 年 2 月] This gene encodes a member of the sialic acid-binding immunoglobulin-like …

Siglec-5 is an inhibitory immune checkpoint molecule for human T cells. Periodontitis Risk Variants at <i>SIGLEC5</i> Impair ERG and MAFB Binding. Mueller R, Chopra A, Dommisch H, Schaefer ASMueller R, et al. J Dent Res, 2022 May. PMID 34852650. Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome.

这个基因编码唾液酸结合免疫球蛋白样凝集素（Siglec）家族的一员。 这些细胞表面凝集素的特点是在免疫球蛋白（Ig）样结构域中的结构基序和第一个Ig V集结构域中的唾液酸识别位点。 编码的蛋白质是Siglec中与CD33相关的子集成员，并抑制包括单核细胞、巨噬细胞和中性粒细胞在内的几种细胞的激活。 B组链球菌（GBS）与编码蛋白的结合在GBS免疫逃逸中起作用。 [RefSeq，2012年2月提供] 当前研究发现，SIGLEC5基因存在3种不同的转录本和3种不同的 …