Dr. Sihan Wu has an extensive background in cancer genetics and genomics. After graduating from Sun-Yat-sen University (SYSU), where he majored in biotechnology in the Life Science School, he obtained his Ph.D. at the Zhongshan School of Medicine at SYSU. His doctoral research focused on how genetic alterations contribute to brain tumor ...

Dr. Sihan Wu has an extensive background in cancer genetics and genomics. After graduating from Sun-Yat-sen University (SYSU), where he majored in biotechnology in the Life Science School, he obtained his Ph.D. at the Zhongshan School of Medicine at SYSU. His doctoral research focused on how genetic alterations contribute to brain tumor ...

The University of Texas Southwestern Medical Center. The long-term goal of our lab is to understand the functions of ecDNA and how ecDNA is maintained in cancer.

Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant …

Sihan WU, Professor (Assistant) | Cited by 2,247 | of University of Texas Southwestern Medical Center, Texas (UT Southwestern) | Read 49 publications | Contact Sihan WU

2021年7月20日 · Dr. Sihan Wu recently became the institute’s tenth faculty member and principal investigator. He earned his Ph.D. at the Zhongshan School of Medicine at Sun-Yat-sen University in 2014, and completed a postdoctoral fellowship at the Ludwig Institute for Cancer Research at the University of California, San Diego, under Dr. Paul Mischel’s ...

During his Ph.D. training, he focused on dissecting the mechanism of DNA demethylation and developing CRISPR-based gene editing tools. In 2023, he joined the Zhijian “James” Chen lab at the Molecular Biology department, co-mentored by Sihan Wu at CRI. Here, he studies the mechanism by which ecDNA-driven cancer evades immune surveillance.

Pan-cancer analyses reveal that oncogenes encoded on ecDNA are among the most highly expressed genes in the transcriptome of the tumours, linking increased copy number with high transcription levels.

2023年11月25日 · 【 查看独家专访 】 Sihan Wu Lab 2021年，吴思涵在美国得克萨斯大学西南医学中心担任PI，专注于ecDNA研究。他的研究工作为现代ecDNA生物学奠定了基础，成为该领域的顶尖科学家之一。

CRI-Lab Sihan Wu; Pediatrics; Assistant Professor, Children's Medical Center Research Institute At Ut Southwestern