Sirpα on tumor-associated myeloid cells restrains antitumor
2024年1月10日 · Sirpa−/− macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa−/− macrophages facilitated T …
Sirpα on tumor-associated myeloid cells restrains antitumor
Sirpa-/-macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa-/-macrophages facilitated T cell recruitment via …
Supporting this, Syk inhibitor GS-9973 prevents podocyte antigen presentation, resulting in a decrease of T cell activation and mitigation of renal disease caused by SIRPa knockdown or …
Podocyte SIRPα reduction aggravates lupus nephritis via …
2024年5月28日 · Here, we report that SIRPα controls podocyte antigen presentation in specific T cell activation via inhibiting spleen tyrosine kinase (Syk) phosphorylation. First, podocyte …
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to …
2020年8月18日 · We found that CD47 ligation altered SIRPA localization, positioning SIRPA for activation at the phagocytic synapse. At the phagocytic synapse, SIRPA inhibited integrin …
PD-L1 monoclonal antibody alleviated MI injury of left ... - PubMed
2025年1月17日 · In vitro Western blotting analysis revealed that PD-L1 mAb can modulate the CD47/SHP2/SIRPα/SYK/FcγR signaling pathway, thereby affecting breast cancer. Treatment …
南科大靳文菲团队发现髓系细胞受体Sirpa不依赖CD47调控肿瘤免 …
2024年1月16日 · 体外实验表明，Sirpa敲除的巨噬细胞可通过Syk/Btk激酶依赖的Ccl8分泌而促进T细胞募集发挥抗肿瘤作用。 此外，研究人员发现Sirpα缺失与抗PD-L1的联合治疗呈现出更强 …
肿瘤相关骨髓细胞上的 Sirpα 抑制结直肠癌的抗肿瘤免疫，与其与 …
Sirpa −/−巨噬细胞表现出强烈的吞噬作用和抗原呈递，以增强 T 细胞的活化和增殖。 此外， Sirpa −/−巨噬细胞通过 Syk/Btk 依赖性 Ccl8 分泌促进 T 细胞招募。
Podocyte SIRPα reduction aggravates lupus nephritis via …
2024年5月28日 · Supporting this, Syk inhibitor GS-9973 prevents podocyte antigen presentation, resulting in a decrease of T cell activation and mitigation of renal disease caused by SIRPα …
Researchers discover that Sirpα on tumor-associated myeloid cells ...
2024年1月16日 · Associate Professor Wenfei Jin from the School of Life Sciences at the Southern University of Science and Technology (SUSTech) led a research group that discovered …
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