Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in …

The Hox genes are a set of transcription factor genes that exhibit an unusual property: They provide a glimpse of one way in which gene expression is translated into the many different forms that...

One family of transcription factors, encoded by the homeobox (HOX) genes, plays a crucial role in Drosophila, Xenopus, and mammalian embryonic differentiation and development. We have previously identified six HOX genes (HOXC6, HOXC8, HOXD1, HOXD4, HOXD8, and HOXD9), by a sensitive PCR-based approach, in a cDNA library prepared from the human ...

2013年10月1日 · Despite the incompleteness of Hox-ε, -ζ, -η, and -θ loci, there is sufficient evidence that Japanese lamprey contains at least six Hox clusters. The singleton Hox4 gene in the Hox-η locus (Hox-η4) is unique in that it comprises four coding exons compared with two exons in most Hox genes and three exons in Hox13 and Hox14 genes (5, 24 –26).

By sequencing bacterial artificial chromosome (BAC) clones and the whole genome, here we provide evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum). This suggests that the lamprey lineage has experienced an …

2009年1月1日 · Motor neurons and several classes of interneurons are generated in response to graded extrinsic signals acting along the dorsoventral axis of the neural tube. These secreted signals include sonic hedgehog (Shh) from the notochord and floor plate, and fibroblast growth factors (FGFs) and retinoic acid (RA) by the paraxial mesoderm.

2013年10月1日 · By sequencing bacterial artificial chromosome (BAC) clones and the whole genome, here we provide evidence for at least six Hox clusters in the Japanese lamprey (Lethenteron japonicum). This suggests that the lamprey lineage has experienced an additional genome duplication after 1R and 2R.

2024年1月19日 · Here, we investigated the role of hox13 genes in caudal fin formation as these genes control posterior identity in animals. Analysis of expression profiles of zebrafish hox13 paralogs and phenotypes of CRISPR/Cas9-induced mutants showed that double hoxb13a and hoxc13a mutants fail to form a caudal fin.

2023年10月16日 · Hox 基因是后生动物身体规划形成、模式化和进化的核心，在无脊椎动物和脊椎动物胚胎发育早期的细胞命运决定中发挥着关键作用。 虽然典型的 Hox 基因簇由九个直向同源组 (HOX1-HOX9) 的成员组成，按照它们具有前后模式效应的顺序紧密连锁排列，但线虫 Hox 基因 ...

In this study, 31 species representing 26 pentatomomorphan and four cimicomorphan putative families were chosen, and six Hox gene fragments with as many as 4 kilobases for each representative...