2024年12月25日 · SLC16A3 (Solute Carrier Family 16 Member 3) is a Protein Coding gene. Diseases associated with SLC16A3 include Autism Spectrum Disorder and Hyperinsulinemic Hypoglycemia, Familial, 7. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Response to elevated platelet cytosolic Ca2+.

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene. [ 5 ] [ 6 ] Northern and western blotting and EST database analyses showed MCT4 to be widely expressed and especially so in glycolytic tissues such as white skeletal muscle fibers, astrocytes , white ...

2019年6月14日 · MCT4 (SLC16A3), which is strongly overexpressed in highly glycolytic and anaerobic tissues, has a low affinity for l-lactate (K m 20–35 mM) and is responsible for L-lactate export 2.

2021年1月1日 · The focus of this review is to highlight novel structural insights obtained from X-ray structures of an L-lactate-transporting SLC16 family homolog. Furthermore, the roles of MCT1 (SLC16A1) and MCT4 (SLC16A3) in human disease (e.g., cancer metabolism and …

2022年2月10日 · 其中，hkdc1是最显著的预后正相关蛋白，slc16a3是最显著的预后负相关蛋白 （图7b） 。 这两种蛋白的丰度在四个 蛋白质组 亚型中也存在显著差异，SLC16A3在S1中上调，HKDC1在S4中升高 （图7C) 。

The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate transporter (MCT) family that play an essential role in the transport of important cell nutrients and for cellular metabolism and pH regulation.

质子连接的单羧酸转运蛋白 (MCT) 家族成员催化乳酸和丙酮酸跨质膜转运，该家族已被指定为溶质载体家族 16。 每种 MCT 似乎具有略微不同的底物和抑制剂特异性以及转运动力学，这与其所在组织的代谢要求有关。 MCT，包括 MCT1 (SLC16A1；MIM 600682) 和 MCT2 (SLC16A7；MIM 603654) ，具有 12 个预测的跨膜结构域 (Price 等人，1998 [PubMed 9425115]) 。 [OMIM 提供，2008 年 3 月]

高 SLC16A3 与 LUAD 而非 LUSC 中的免疫抑制细胞（Treg、Th2 和 iDC）、免疫检查点（PD1、PD-L1、PVR、Tim-3、ITGAM）和免疫抑制因子（foxp3、TGF-β）相关。 此外，SLC16A3 与 IL-8 紧密相互作用，可诱导微环境免疫耐受。

Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming. Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line.

The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane …