2024年12月25日 · SLC17A6 (Solute Carrier Family 17 Member 6) is a Protein Coding gene. Diseases associated with SLC17A6 include Arthrogryposis, Distal, Type 2A and Von Economo's Disease. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Neuroscience.

2025年2月8日 · Enables L-glutamate uniporter activity. Involved in L-glutamate import and phosphate ion homeostasis. Located in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Feb 2025]

Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3. Aihara Y, et al . Cytogenet Cell Genet, 2001.

FlpO expression/activity largely recapitulates the endogenous Slc17a6 gene in the brain - widespread throughout most of the brain, except very sparse expression in striatum and restricted populations within cerebellum, medulla and pons.

Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. The RNA data was used to cluster genes according to their expression across cell lines.

2025年2月11日 · Acts upstream of or within neurotransmitter uptake. Located in synaptic vesicle. Is expressed in several structures, including cranial ganglion; nervous system; sensory organ; tail mesenchyme; and testis. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Feb 2025]

2021年1月12日 · Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear. Heterologous expression of all three VGLUTs greatly augments intracellular Pi levels.

The main solute carrier transporters involved in glutamate/GABA-glutamine cycle. Glutamate is packaged into synaptic vesicles in pre-synaptic neurons by SLC17A6/A7. After release into the synaptic cleft and stimulating post-synaptic neurons, the signal is terminated by astroglial uptake of glutamate via SLC1A2/A3.

2011年8月3日 · SLC17A6 contains 8 putative transmembrane segments. SLC17A6 shares 82% sequence identity with SLC17A7 (605208), which the authors called BNPI, and 48% identity with EAT4, a sodium-inorganic phosphate cotransporter of C. elegans.

View mouse Slc17a6 Chr7:51271754-51320867 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression