2024年12月25日 · SLC29A1 (Solute Carrier Family 29 Member 1 (Augustine Blood Group)) is a Protein Coding gene. Diseases associated with SLC29A1 include Hemolytic Disease Of The Fetus and Myeloproliferative Neoplasm. Among its related pathways are Drug ADME and Fluoropyrimidine activity.

2025年1月30日 · Here, we demonstrate that equilibrative nucleoside transporter 1 and 2 (ENT1 and 2, encoded by SLC29A1 and 2) drive cellular nicotinamide uptake and establish nicotinamide metabolism homeostasis.

Data suggest that SLC29A1 is located on basolateral membrane of adult Sertoli cells; SLC29A1 is primarily responsible for basolateral nucleoside uptake into Sertoli cells. In contrast, SLC29A2 is localized to apical membrane of Sertoli cells.

Here, the authors show that equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), encoded by the genes SLC29A1 and SLC29A2, function in nicotinamide uptake into cells. Nicotinamide (NAM), an active form of vitamin B3, is widely studied and utilized for its antiaging, metabolic regulation, organ protective and reparative effects 1, 2.

2025年1月30日 · Here, we demonstrate that equilibrative nucleoside transporter 1 and 2 (ENT1 and 2, encoded by SLC29A1 and 2) drive cellular nicotinamide uptake and establish nicotinamide metabolism homeostasis. In addition, ENT1/2 exhibits a strong capacity to change the cellular metabolite composition and the transcript, especially those related to nicotinamide.

We systematically screened the expression of transporter genes in HCC samples and found that solute carrier family 29 member A1 (SLC29A1) expression was significantly elevated in human HCC cells compared with para-carcinoma cell samples.

2017年12月1日 · We systematically screened the expression of transporter genes in HCC samples and found that solute carrier family 29 member A1 (SLC29A1) expression was significantly elevated in human HCC cells compared with para-carcinoma cell samples.

The current study demonstrated that SLC29A1 mediates AZA uptake in leukemia cell lines and, importantly, provided mechanistic data linking AZA resistance with lower intracellular concentration of AZA, which is predominantly mediated …

2024年12月9日 · Clinical resource with information about SLC29A1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2025年2月8日 · results establish Augustine as a new blood group system and place SLC29A1 as a new candidate gene for idiopathic disorders characterized with ectopic calcification/mineralization. Findings demonstrate that ENT1 regulates GFAP expression and possibly astrocyte function