2024年12月25日 · SLC32A1 (Solute Carrier Family 32 Member 1) is a Protein Coding gene. Diseases associated with SLC32A1 include Generalized Epilepsy With Febrile Seizures Plus, Type 12 and Developmental And Epileptic Encephalopathy 114.

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene. [5] The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [5]

2025年2月18日 · Used to study temporal lobe epilepsy. Human ortholog (s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Feb 2025]

The VIAAT protein, encoded by SLC32A1, is the only known protein in human and other mammals capable of transporting the inhibitory neurotransmitters GABA and glycine into synaptic vesicles (Fig. 4) and it is crucial for the function of the vertebrate nervous system.

The SLC32 family comprises a single member: the vesicular inhibitory amino acid transporter (VIAAT) or vesicular GABA transporter (VGAT). It belongs to a eukaryotic-specific superfamily of H (+)-coupled amino acid transporters, which also comprises the mammalian SLC36 and SLC38 transporters. VIAAT exchanges GABA or glycine for protons.

2025年2月8日 · Gene ID: 140679, updated on 8-Feb-2025. The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]

2023年6月1日 · SLC32A1 是一种氨基酸转运蛋白，可将 GABA 和甘氨酸装载到突触小泡中（Jellali 等人总结，2002）。 麦金太尔等人（1997） 鉴定出 Slc32a1 或 Unc47 是线虫中的囊泡 γ-氨基丁酸（GABA） 转运蛋白（VGAT）。 线虫 Unc47 含有 486 个氨基酸，具有 10 个跨膜结构域。 荧光标记的 Unc47 仅在秀丽隐杆线虫的 GABA 能神经元中表达，并定位于沿腹侧和背侧索的突触小泡。 作者还克隆了大鼠 Unc47 直向同源物，它编码 525 个氨基酸的蛋白质，与秀丽隐 …

View mouse Slc32a1 Chr2:158452687-158457668 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Predicted to enable gamma-aminobutyric acid:proton symporter activity and glycine transmembrane transporter activity. Involved in several processes, including gamma-aminobutyric acid transport; hippocampus development; and neurotransmitter loading into synaptic vesicle. Located in inhibitory synapse and synaptic vesicle.

2020年3月1日 · GABA is packaged into synaptic vesicles by SLC32A1 and released into the synaptic cleft. SLC6A11 and SLC6A1 are responsible for GABA uptake in astrocytes and neurons, respectively. GABA is metabolized to α-ketoglutarate (α-KG) …