2024年12月25日 · SLC7A1 (Solute Carrier Family 7 Member 1) is a Protein Coding gene. Diseases associated with SLC7A1 include Tinea Capitis and Trichothiodystrophy 2, Photosensitive. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Nanog in Mammalian ESC Pluripotency.

阳离子氨基酸转运蛋白 SLC7A1 (CAT1) 是 T 细胞重要的精氨酸转运蛋白， SLC7A2 (CAT2) 对先天免疫至关重要。 SLC 氨基酸转运蛋白与炎症和自身免疫之间的联系有助于更好地去了解疾病的潜在机制并提供新的潜在治疗途径。 图3. SLC1A1, SLC1A2和SLC1A3在CNS中的作用。 3. Amino Acid Solute Carrier...

Enables L-arginine transmembrane transporter activity and L-histidine transmembrane transporter activity. Involved in amino acid transport. Located in membrane. Part of apical plasma membrane; basolateral plasma membrane; and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT. High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies.

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene. [5] [6]

2022年9月12日 · Cationic amino acid transporters (SLC7A1/CAT1) are highly expressed in human ovarian cancer (OC) tissues. However, the specific biological functions and mechanisms involved remain unclear. We used bioinformatics analysis to explore SLC7A1 expression level, prognostic value, and tumor mutation burden …

溶质载体家族成员SLC7A11（Solute Carrier Family 7 Member 11，又名xCT）是溶质转运第7家族的第11个成员，属于 胱氨酸/谷氨酸逆向转运蛋白，主要参与氨基酸在质膜上的转运 [9, 10]。

2025年1月22日 · Single-cell analysis indicated that SLC7A1 was predominantly expressed in osteosarcoma cells and correlated with various malignant tumor characteristics. SLC7A1 also regulate interactions between tumor cells and macrophages, as well as modulate macrophage function through multiple pathways.

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. Optimum pH is 5.5-8.5. Gene Ontology (GO) annotations organized by slimming set. Showing features for topological domain, transmembrane. We now provide the "Disease & Variants" viewer in its own tab.

2018年2月7日 · In mammals, cellular arginine availability is determined by members of the solute carrier (SLC) 7 family of cationic amino acid transporters. Whereas CAT-1 functions to supply cationic amino acids...