Smad（由线虫的Sma和果蝇的Mad缩写而来）蛋白是TGF-β家族受体下游的信号转导分子。在哺乳动物中总共存在八个Smad蛋白（Smad1到Smad8）。 根据在TGF-β信号转导中的功能差异，它们被分为三类： ① 包括受体调控的Smad（receptor-regulated Smad， R-Smad – Smad1/2/3/5/8）

The human homologue of Mad and Sma was named Smad1, a portmanteau of the previously discovered genes. When injected into Xenopus embryo animal caps, Smad1 was found to be able to reproduce the mesoderm ventralizing effects that BMP4 , …

2024年12月25日 · SMAD1 (SMAD Family Member 1) is a Protein Coding gene. Diseases associated with SMAD1 include Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome and Hermansky-Pudlak Syndrome 2. Among its related pathways are Gene expression (Transcription) and Transcriptional regulation of brown and beige adipocyte differentiation.

Smad蛋白（Smad是由线虫的Sma和果蝇的Mad缩写而来） 是TGF-β家族受体下游的信号转导分子[1,2]。在哺乳动物中有八个Smad蛋白, Smad1、 Smad1、 ...、 Smad8。 根据在TGF-β信号转导中的功能差异，它们被分为三类： 与其它跟许多激酶 - 底物反应一样， TGF- β I 型受体对 R-Smad 的磷酸化需要它们的直接结合。

Smads家族蛋白在将 TGF -β信号从 细胞表面受体 传导至 细胞核 的过程中起到关键性作用，且不同的Smad介导不同的TGF-β家族成员的信号转导。 TGF-β作为 配体 形成的受体复合物，激活Smads进入核内，共同激活或抑制它们调节的 靶基因 的转录。 Smads蛋白家族：根据结构，Smad蛋白分成R-Smad，Co－Smad和I-Smad 3个 亚家族，至少包括，用Smad l－9表示，按功能分为3类：即受体活化型或通路限制性Smad (R－Smads)、共同通路型Smad (Co－Smad) …

Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene. [4][5] SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ' mothers against decapentaplegic ' (Mad) and the C. elegans gene Sma. [citation needed] .

2021年6月16日 · This study identifies SMAD1 regulation of NF-κB1/TNFAIP8 and ID1-p21/p27 as critical axes of MM drug resistance and provides a potentially new therapeutic strategy to treat drug resistance MM through targeted inhibition of SMAD1.

SMAD1 signaling may be a key pathway contributing the pathogenesis of Cardio-facio-cutaneous syndrome during early development. Smad1 elevation serves as a compensatory mechanism for p53 deficiency by potentiating the activation of p53 parallel pathways.

The expression levels of SMAD proteins have an important impact on the tumour microenvironment and therapeutic efficacy. Studies have shown that SMAD1 is highly expressed in cisplatin-resistant gastric cancer cells and that SMAD1 interacts with YAP1, leading to the increased resistance of gastric cancer cells to cisplatin .

2024年12月4日 · Smad1 forms a complex with p53 and p300, inhibiting p300's interaction with p53 and leading to reduced p53 acetylation and increased Smad1 acetylation in GBM. This results in enhanced tumor growth and resistance to chemotherapy, particularly in tumors with missense mutant p53.