2024年12月25日 · SMAD9 (SMAD Family Member 9) is a Protein Coding gene. Diseases associated with SMAD9 include Pulmonary Hypertension, Primary, 2 and Heritable Pulmonary Arterial Hypertension. Among its related pathways are TGF-beta receptor signaling in skeletal dysplasias and TGF-Beta Pathway.

SMAD9, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members, SMAD9 is …

2014年12月23日 · Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5 and Smad9...

Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad DVD).

Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.

2025年2月8日 · findings suggest that Smad9 is a new type of transcriptional regulator in BMP signaling. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2/Smad1/5/8 and Wnt/beta-catenin pathways.

该基因编码的蛋白质是 SMAD 家族的成员，它转导来自 TGF-β 家族成员的信号。 编码的蛋白质被骨形态发生蛋白激活并与 SMAD4 相互作用。 已为该基因发现编码不同亚型的两个转录变体。 [RefSeq 提供，2010 年 1 月] The protein encoded by this gene is a member of the Smad Family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4.

cox单因素分析结果显示，smad9表达水平与肺腺癌患者生存率显著相关(hr=0.870，95%ci=0.776~ 0.976，p < 0.05)，说明smad9表达量是肺腺癌患者生存的保护因素；进一步对可能影响肺腺癌患者生存预后的临床特征进行单因素分析发现，t分期、n分期、肿瘤分期等因素均为其 ...

2014年12月23日 · Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by …

Our findings support SMAD9 as a novel HBM gene and a potential novel osteoanabolic target for osteoporosis therapeutics. SMAD9 is thought to inhibit bone morphogenetic protein (BMP)-dependent target gene transcription to reduce osteoblast activity.