
上皮间质转化(EMT)4种标志物介绍 - 知乎 - 知乎专栏
上皮间质转化(epithelial-mesenchymal transition,EMT)是上皮细胞向间充质细胞转化的一个过程,上皮细胞失去顶基细胞极性,失去粘附性并获得间充质细胞的表型,获得间充质细胞迁移 …
转录因子Snail与肿瘤的上皮细胞间质化 - PMC
EMT是肿瘤发展的决定因素,E-cadherin的表达降低或缺失是EMT发生的标志,而Snail通过抑制E-cadherin的表达来促进EMT的发生。Snail在浸润性乳腺癌的上皮及内皮细胞中过表达,而在正 …
The Role of Snail in EMT and Tumorigenesis - PubMed
Snail is a zinc-finger transcriptional repressor controlling EMT during embryogenesis and tumor progression. Through its N-terminal SNAG domain, Snail interacts with several corepressors …
国自然划重点:红透半边天的EMT机制研究及相关通路 - 知乎
参与EMT的常见信号通路. 由于EMT涉及的信号通路众多,只能介绍几种影响最大的通路: TGF-β信号通路 、Wnt信号通路、 Notch信号通路 ,都是些老朋友了。 1.TGF-β信号通路. TGF-β …
表观遗传学第四讲——EMT过程中的表观遗传修饰 - 知乎
上皮-间充质转化(emt)是一种生物学过程,非运动的、极化的上皮细胞经历一系列的生化改变,成为具有侵袭能力、抗凋亡和细胞外基质(ecm)成分生物合成改变的运动的、非极化的间充质细 …
The Role of Snail in EMT and Tumorigenesis - PMC - PubMed …
As a key transcriptional repressor of E-cadherin expression in EMT, Snail plays an important role in embryonic development and cancer progression. Emerging evidences indicate that Snail …
上皮间质转化(EMT):细胞命运转变的关键过程
2025年1月16日 · 上皮间质转化(epithelial-mesenchymal transition,简称EMT)作为这一过程中的关键一环,不仅参与胚胎发育、伤口愈合等生理过程,更在器官纤维化和肿瘤转移等病理状 …
Non-canonical functions of SNAIL drive context-specific cancer
2023年3月7日 · SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a master regulator of...
Central role of Snail1 in the regulation of EMT and resistance in ...
Snail1 has a pivotal role in the regulation of epithelial-mesenchymal transition (EMT), the process by which epithelial cells acquire a migratory, mesenchymal phenotype, as a result of its …
Ets 家族蛋白调节癌细胞中的 EMT 转录因子 Snail 和 ZEB,FEBS …
2022年4月22日 · 上皮 - 间质转化(EMT)是上皮肿瘤进展过程中发生的关键形态事件。Snail 和 ZEB1/2(ZEB1 和 ZEB2)被称为 EMT 转录因子,是这一转变的关键调节因子。ZEB1/2 与 …
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