1 Introduction. Store-operated calcium entry (SOCE) is a ubiquitous Ca 2 + entry pathway that is activated in response to stimulation of plasma membrane receptors that are coupled to PIP 2 hydrolysis, IP 3 generation, and IP 3-mediated Ca 2 + release from the endoplasmic reticulum (ER). The primary trigger for activation of SOCE is the depletion of the ER-Ca 2 + store, while refilling of this ...

2017年10月17日 · Store-operated Ca 2+ entry (SOCE) is the main Ca 2+ influx pathway in lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by Ca 2+ release-activated Ca 2+ (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2. SOCE regulates many Ca 2+-dependent signaling molecules, including calcineurin, and inhibition of SOCE or calcineurin ...

2016年2月26日 · SOCE is necessary for G1/S transition. We first performed a protocol of cell cycle synchronization to determine whether Ca 2+ signaling plays an important role in cell cycle progression ().The ...

Store-operated Ca(2+) entry (SOCE) is an ubiquitous and major mechanism for Ca(2+) influx in mammalian cells with important physiological relevance. Since the discovery of SOCE in 1986 both, the mechanism that communicates the amount of Ca(2+) accumulated in the intracellular Ca(2+) stores to the pl …

Abstract. Calcium signals play a critical role in many cell-type specific effector functions during innate and adaptive immune responses. The predominant mechanism to raise intracellular [Ca 2+] used by most immune cells is store-operated Ca 2+ entry (SOCE), whereby the depletion of endoplasmic reticulum (ER) Ca 2+ stores triggers the influx of extracellular Ca 2+.

2017年3月15日 · Although abolished SOCE, T cell dysfunction and immunodeficiency in these patients indicate that ORAI1 is the dominant CRAC channel subunit in human effector T cells, these findings do not exclude ...

2023年12月26日 · Carreras-Sureda et al. report that IRE1 protein facilitates STIM1 to gate ORAI channels in ER-PM contact sites and SOCE, supporting T cell activation and myoblast differentiation. Noteworthily, STIM1 promotes IRE1 signaling upon store depletion. Finally, whole-genome CaMPARI screening identifies CAMK2G and SLC1A5 as …

2012年1月1日 · Calcium signals play a critical role in many cell-type specific effector functions during innate and adaptive immune responses. The predominant mechanism to raise intracellular (Ca²⁺) used by most immune cells is store-operated Ca²⁺ entry (SOCE), whereby the depletion of endoplasmic reticulum (ER) Ca²⁺ stores triggers the influx of extracellular Ca²⁺.

2023年4月8日 · Introduction. Store-operated Ca 2+ entry (SOCE; Fig. 1) is a mechanism that links the two main Ca 2+ sources underlying cytoplasmic Ca 2+ signals in the cell: the extracellular space and the primary intracellular Ca 2+ store, the endoplasmic reticulum (ER). Following agonist-dependent release of Ca 2+ from the ER, SOCE allows for the replenishment of depleted intracellular stores and is ...

2016年10月5日 · SOCE refers to a unique Ca 2+ entry route that is specifically activated by depletion of Ca 2+ from the endoplasmic reticulum (ER). The existence of SOCE was first formulated by Jim Putney in 1986 in a visionary paper that transformed the Ca 2+ signaling field .SOCE (originally called capacitative Ca 2+ entry) was later shown to be the primary Ca 2+ entry pathway in non-excitable cells.