SERCA2a controls the mode of agonist-induced ... - ScienceDirect
2011年4月1日 · SERCA2a controls the kinetic of agonist-induced Ca 2+ transient in VSMC. Steady-state Ca 2+ transient results in STIM1/ORAI association and SOCE opening. Oscillatory Ca 2+ transient prevents STIM1/ORAI association and SOCE opening. SERCA2a expression inhibits proliferation-associated SOCE/NFAT pathway.
SERCA2a controls the mode of agonist-induced intracellular Ca2
Furthermore, we demonstrated that SERCA2a inhibits the activation of STIM1/ORAI1 dependent SOCE and the downstream PP2B/NFAT signaling pathway by modifying the agonist-induced intracellular Ca 2+ transient from steady-state to an oscillatory mode.
陈帅教授课题组发现心脏钙稳态调控新机制 - NJU
该研究从蛋白质组学入手，发现SERCA2a可以与横纹肌特异性表达的蛋白激酶（SPEG）相互作用；通过一系列深入研究证明了SPEG是SERCA2a的一个全新调控因子，可调控钙离子在细胞浆与肌浆网之间的穿梭（图一）。 这项研究揭示了心脏钙稳态调控的一种新机制，为钙稳态异常导致的心脏疾病的发病机理及治疗提供了新思路。...
SERCA2 phosphorylation at serine 663 is a key regulator of Ca
2023年6月8日 · Here, we discover that sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase (SERCA2) phosphorylation at serine 663 is a clinical and pathophysiological event of cardiac function. Indeed, the...
SERCA control of cell death and survival - ScienceDirect
2018年1月1日 · Altered SERCA function leads to elevated cytosolic Ca 2+, resulting in cellular malignancy and ER stress-associated apoptosis and organ damage. Ca 2+ homeostasis and SERCA function represent a nodal point that controls cell survival. Pharmacological or genetic targeting of this axis constitutes a great therapeutic potential for many diseases.
SERCA2a controls the mode of agonist-induced intracellular Ca2 …
Here, we report that in human coronary artery smooth muscle cells (hCASMCs), the sarco/endoplasmic reticulum calcium ATPase type 2a (SERCA2a) expressed in the contractile form of the hCASMCs, controls the nature of the agonist-induced Ca (2+) transient and the resulting down-stream signaling pathway.
SERCA2a controls the mode of agonist-induced intracellular Ca
2011年4月1日 · SERCA2a controls the kinetic of agonist-induced Ca 2+ transient in VSMC. Steady-state Ca 2+ transient results in STIM1/ORAI association and SOCE opening. Oscillatory Ca 2+ transient prevents STIM1/ORAI association and SOCE opening. SERCA2a expression inhibits proliferation-associated SOCE/NFAT pathway.
SERCA2a: a key protein in the Ca 2+ cycle of the heart failure - PubMed
The sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2a (SERCA2a) acts as a subtype of SERCA expressed in the heart, which mediates the contraction of cardiomyocytes and Ca 2+ in the cytoplasm to re-enter into the SR. The rate of uptake of Ca 2+ by the SR determines the rate of myocardial relaxation. The regulation of SERCA2a activity controls ...
The endoplasmic reticulum luminal Ca2+ regulates cardiac Ca2
2025年2月7日 · By measuring the endoplasmic reticulum [Ca 2+] ( [Ca 2+] ER) with the Ca 2+ sensor R-CEPIA1er, we characterized the function of recombinant human and native mouse SERCA2a. We found that despite low endoplasmic reticulum (ER) Ca 2+ gradient, SERCA2a-mediated Ca 2+ transport was significantly slower at low …
Sarcoplasmic Reticulum Ca2+ Dysregulation in the …
2022年6月1日 · SR not only controls Ca 2+ flux through various channels (RyR2 and IP3R), pumps (SERCA2a) and corresponding regulators (CASQ2, CaM, FKBP12.6, junctin, triadin, PLN and SLN) but also regulates Ca 2+ levels in different subcellular by forming specific structures with mitochondrion (IP3R/GRP75/VDAC1/DJ-1 complex at MAM is the major contributor to r...