2023年4月12日 · We found that IL-6 turned off IL-2 signaling during early T-cell activation and thus inhibited Th2 priming. Mechanistically, IL-6-driven inhibition of IL-2 signaling in …

Seki and colleagues suggest SOCS5 interacts via its N-terminus with the IL-4 receptor alpha (IL-4Rα) Box 1 region, blocking JAK1 association and subsequent Th2 differentiation. Indeed, …

We found that IL-6 turned off IL-2 signaling during early T-cell activation and thus inhibited Th2 priming. Mechanistically, IL-6-driven inhibition of IL-2 signaling in responding T cells was …

SOCS proteins regulate cytokine signals that control the polarization of CD4 + T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8 + T cells from naïve to “stem …

2023年5月17日 · 总的来讲，本文研究结果表明，在过敏原特异性的T细胞中，IL-6信号对于通过抵消IL-2驱动的促Th2信号来预防Th2的发育非常重要；本文研究识别出了一 ...

2024年11月28日 · SOCS2 expression is induced by the activation of the JAK3/STAT5 pathway, and to a lesser extent STAT6. Cytokines which stimulate this pathway are predominantly IL-2, …

2020年7月13日 · As for SOCS6, the neuronal differentiation process by SOCS6 is suggested to be enhanced by IGF-1, which stimulates STAT5 activation, leading to up-regulation of SOCS6. …

2023年2月15日 · The overexpression of SOCS6 results in the repression of TCR-dependent IL-2 promotion and activation of MAPK pathway factors, such as ERK1/2 and p38 . SOCS6 also …

Recently, heterozygous loss-of-function germline mutations in SOCS1 have been shown to be associated with early onset human autoimmune diseases, with lymphocytes showing …

2022年4月1日 · Ectopic transduction of SOCS6 in lymphoma NKYS and YT cell lines has been demonstrated to contribute to negative selection pressure, and increase apoptosis in IL-2 …