SONIA 2 was a 4-year, open-label, evaluator-blind, multicentre, randomised, no treatment controlled, parallel-group study to investigate the efficacy and safety of nitisinone for patients …

2019年1月22日 · On the 18th January, the last SONIA 2 (Suitability of Nitisinone In Alkaptonuria 2) patients were seen at the Royal Liverpool and Broadgreen University Hospital.

2019年12月16日 · We are delighted to announce that all the data from the SONIA 2 clinical trial has now been analysed and very positive trends have been highlighted. Due to this, SOBI …

The aim of SONIA 2 was to investigate the efficacy and safety of once-daily nitisinone for reducing HGA excretion in patients with alkaptonuria and to evaluate whether nitisinone has a clinical …

Based on the SONIA-2 results, the use of nitisinone (Orfadin R) 10 mg daily has been officially approved by the European Medicines Agency (EMA) in September 2020 for the treatment of …

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The aim of SONIA 2 was to investigate the efficacy and safety of once-daily nitisinone for reducing HGA excretion in patients with alkaptonuria and to evaluate whether nitisinone has a clinical …

SONIA 2: An international, multicenter, randomized, evaluator-blinded, no-treatment controlled, parallel-group study to assess the efficacy and safety of once daily nitisinone in patients with …

2014年7月30日 · Our SONIA 2 clinical trial is underway at all our sites across Europe. Conducting such a complex trial across three countries is not easy, but the teams at each centre have …

The aim of SONIA 2 was to investigate the efficacy and safety of once-daily nitisinone for reducing HGA excretion in patients with alkaptonuria and to evaluate whether nitisinone has a clinical …