2001年10月23日 · Some loading regimens involve giving either 600 mg per day for 4 weeks (123) or greater than or equal to 1 g per day for 1 week (124) followed by lower maintenance doses. …

2024年2月26日 · Intravenous loading of sotalol is recommended to facilitate the initiation of oral sotalol therapy. Sotalol is also used as an off-label medication for pharmacological …

The DASH-AF (Feasibility and Safety of Intravenous Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy in Adult Patients With Atrial Fibrillation) trial evaluates the safety …

This novel IV sotalol load could decrease the length of hospital admission, decrease overall admission cost, and improve patient satisfaction. We describe the first use of a single-dose IV …

2024年2月26日 · Loading of oral sotalol for atrial fibrillation requires 3 days, frequently in the hospital, to achieve steady state. The Food and Drug Administration approved loading with …

2025年2月1日 · Rapid intravenous (IV) sotalol loading over 60 minutes for atrial arrhythmias achieves the maximum plasma concentration (Cmax) steady state in <24 hours in patients …

2023年4月1日 · DASH-AF demonstrates that rapid loading of sotalol using an IV starter regimen is feasible and safe compared with the conventional oral loading protocols. Repolarization …

Oral sotalol is commonly used for rhythm control in patients with recurrent symptomatic atrial fibrillation (AF). The drug is usually initiated in the hospital for the first 5 doses, resulting in a 3 …

The aim of this study is to develop an intravenous to oral loading regime for sotalol therapy that reduces the 3-day in-hospital initiation or dose escalation with oral administration to 1 day …

The FDA approved loading with intravenous (IV) sotalol through model-informed development, without patient data. We present results of the first, multicenter, prospective evaluation of this …