2017年9月22日 · Results: It is important that pathologists and surgeons recognize that spindle cell type MPNST may arise in benign schwannoma, as this recognition aids in assessment of patients with schwannoma and contributes to the pathologist making a more precise diagnosis, and the surgeon better determining the appropriate therapeutic options and surgical ...

2015年1月8日 · Deep schwannomas and deep low-grade spindle cell tumors demonstrated fewer statistically significant differentiating features than superficial tumors. The number of clusters, few to no single cells, presence of Verocay bodies, and anisonucleosis were not found to be as statistically significant for deep-seated tumors as they were for ...

Histological examination shows a tumor with compact areas composed of spindle cells alternating with loose areas with collection of lipid laden macrophages. What is the most likely diagnosis? C. Schwannoma. Fibrous meningioma may localize in the spine but it does not feature alternating compact and loose areas or lipid laden macrophages.

Most spindle cell tumors that have been reported to date are associated with malignant tumors, and no cases of spinal schwannoma have been reported thus far. A 38-year-old man presented with lower back pain, lower extremity tingling sensations, and gait disturbance with disequilibrium.

In summary, the presence of Schwannian whorls, a peritumoral capsule, subcapsular lymphocytes, macrophage-rich infiltrates, and absence of fascicles favor the diagnosis of cellular schwannoma, while the presence of perivascular hypercellularity, tumor herniation into vascular lumens, and necrosis favor malignant peripheral nerve sheath tumor.

Cohesive tissue fragments with fibrillary/fibrous stroma, intranuclear inclusions, marked nuclear pleomorphism, and the absence of spindled cells with bipolar cytoplasmic processes are strongly suggestive of schwannoma and assist in excluding potential mimics.

2013年12月1日 · Here, we present an extraordinary case of spindle cell–type malignant peripheral nerve sheath tumor arising in a schwannoma on the back of a 58-year-old woman without neurofibromatosis. The malignant component showed hypercellular spindle cell proliferation with high mitotic activities; in contrast, the benign component showed hypocellular ...

Malignant peripheral nerve sheath tumor (MPNST) is also termed as spindle cell malignancy of the peripheral nerve Schwann cell. It is a rare and highly aggressive, soft-tissue sarcoma of ectomesenchymal origin that accounts for 10% of all sarcomas and only 10%–12% of all lesions occur in the head-and-neck region, thus making it a rare entity.

2017年9月1日 · Malignant peripheral nerve sheath tumor (MPNST) arising in benign schwannoma with multiple intraosseous spinal metastasis is extremely rare, having a highly aggressive progression and poor prognosis. In such cases, the malignant cells of MPNST usually have an epithelioid morphology.

carcinoma, melanoma and follicular dendritic cell sarcoma can present in soft tissue locations and thereby enter the differential diagnosis. Synovial sarcoma is diagnostically obvious when biphasic. The monophasic form is a spindle cell sarcoma composed of closely packed uniform cells with …