迄今最大队列研究SPOP突变前列腺癌患者的基因组特征和预后
Jun 2, 2022 · 最近的研究表明，在正常前列腺细胞中诱导spop突变足以促进致癌染色质重塑，增加dna可及性和ar结合。这些发现为spop突变的临床意义提供了一个机制基础，可能对ar介导的 …
Dual functions of SPOP and ERG dictate androgen therapy
Feb 2, 2021 · ERG upregulates wild type SPOP to dampen androgen receptor (AR) signaling and sustain ERG activity through degradation of the bromodomain histone reader ZMYND11. …
E3泛素连接酶接头蛋白SPOP抑制前列腺癌的研究进展
Jun 21, 2020 · spop以ar依赖性方式促进ar蛋白的泛素化和蛋白酶体降解，并抑制ar介导的pca细胞的生长 。 AR的可变剪接是其中一种重要机制，AR的铰链结构域中具有SBC基序 645 ASSTT …
G3BP1 inhibits Cul3 SPOP to amplify AR signaling and promote ... - Nature
Nov 18, 2021 · Transcriptomic analysis and functional studies reveal a G3BP1-SPOP ubiquitin signaling axis that promotes PCa progression through activating AR signaling. Moreover, AR …
SPOP and cancer: a systematic review - PMC - PubMed Central …
Both of these studies found that SPOP binds to, ubiquitinates, and degrades AR in a manner that is disrupted by prostate cancer-associated SPOP mutations, and that this subsequently …
The diverse roles of SPOP in prostate cancer and kidney cancer
Apr 30, 2020 · In prostate cancer, SPOP targets multiple oncoproteins, such as androgen receptor (AR), Cdc20, Myc, ERG, steroid receptor coactivator 3 (SRC3), PDL1 and BRD4, for …
SPOP that AR! Misregulated Degradation of Androgen Receptor …
Feb 6, 2014 · In a paper published today in Cell Reports, Haojie Huang and colleagues show that an E3 ubiquitin ligase, SPOP, is a key player in the regulation of the stability of AR. The …
【协和医学杂志】前列腺癌体系突变及治疗研究进展-MedSci.cn
SPOP基因突变可激活并上调雄激素受体（AR）表达，其表达水平明显高于ERG-TMPRSS2融合阳性的肿瘤，因此AR表达上调已成为SPOP基因突变阳性前列腺癌的关键特征，其通过稳定组蛋 …
Prognostic and Predictive Role of SPOP Mutations in
Dec 1, 2024 · Multiple lines of evidence suggest that PC with an SPOP gene mutation (SPOP-mutant [SPOPmut] PC) is exquisitely driven and dependent on AR signaling, as SPOPmut …
揭秘SPOP突变前列腺癌耐药机制 - 知乎 - 知乎专栏
该研究首次发现brd2、brd3和brd4（bet蛋白，一类可以和 乙酰化组蛋白 结合的表观遗传学调控蛋白）是spop的作用底物。正常细胞中spop通过蛋白酶体途径促进bet蛋白的 泛素化 降解， …