2024年12月25日 · SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Renal Hypodysplasia/Aplasia 1 and Legius Syndrome. Among its related pathways are Signaling by EGFR and Nuclear receptors meta-pathway. An important paralog of this gene is SPRY2.

2023年10月12日 · Here, we perform single-cell RNA-sequencing of tumors from patients with ESCC undergoing neoadjuvant ICB, revealing a subset of exhausted CD8 + T cells expressing SPRY1 (CD8 + Tex-SPRY1) that displays a progenitor exhausted T cell (Tpex) phenotype and correlates with complete response to ICB.

2025年2月9日 · Increased SPRY1 expression activates NF-kappaB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis. Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.

2024年9月25日 · SPRY1（Sprouty homolog 1）蛋白是一类保守的信号转导调控因子，最早在果蝇. 中发现，随后在哺乳动物中被广泛研究。 SPRY1的主要功能是通过负向调控Ras/M. APK信号通路，影响多种生物过程，如细胞增殖、分化、迁移和器官发育。 本文将. 详细探讨SPRY1在信号调控中的功能性验证实验，揭示其在细胞信号调控中的重要. 作用及实验验证方法。 1. 实验设计与背景. SPRY1作为信号调控蛋白，主要参与抑制生长因子受体信号通路，特别是FGF（成. 纤 …

2023年4月4日 · SPRY1 knockdown suppressed tumor growth in mice. SPRY1 was found to promote CXCL12 expression and facilitate neutrophil and macrophage infiltration via CXCL12-CXCR4 axis. Pharmacological inhibition of CXCL12-CXCR4 largely abrogated the oncogenic functions of SPRY1 by suppressing neutrophil and macrophage infiltration.

2024年4月26日 · Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling conserved from flies to humans [1]. In mice, Spry genes mainly antagonize signaling by...

This gene has 9 transcripts (splice variants), 188 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 30.2), gall bladder (RPKM 30.0) and 25 other tissues. 参与成纤维细胞生长因子受体信号通路的负调控。 位于高尔基体；胞质溶胶；和核质。 [由基因组资源联盟提供，2022 年 4 月] Involved in negative regulation of Fibroblast …

SPRY1 was identified as a key gene within modules linked to skin aging. Single-cell sequencing revealed its enrichment in macrophages and keratinocytes. Knockdown of SPRY1 in RAW264.7 cells resulted in a shift from M1 to M2 macrophage polarization, reduced oxidative stress, and decreased expression of inflammatory markers.

Spry基因家族成员作为纤维组织母细胞生长因子(FGF)诱发的受体酪氨酸激酶(RTK)信号转导通路中的抑制因子,可能具有抑制血管重建和肿瘤发生作用.研究报道显示Spry1主要通过调节Ras-Raf-MEK-MAPK传导通路信号输出的强度和时间,控制细胞周期,抑制细胞增殖,影响细胞的 ...

SPRY1 could facilitate cell proliferation and cell cycle progression, and suppress cell apoptosis via activating the Hedgehog pathway in AML.