2024年12月25日 · SSTR3 (Somatostatin Receptor 3) is a Protein Coding gene. Diseases associated with SSTR3 include Vipoma and Pituitary Adenoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.

2025年2月8日 · Beta cell primary cilia mediate somatostatin responsiveness via SSTR3. HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.

Data indicate that somatostatin receptor scintigraphy (SRS) and immunohistochemical results for somatostatin and dopamine receptors sstr2, sstr3, sstr5 and D2R were compared in neuroendocrine neoplasms tissues. findings provide new insights in understanding the antiproliferative role of SSTR3 in breast tumor biology.

Somatostatin receptors (SSTR) are expressed in various neoplasms and can be targeted for both diagnostics as well as therapeutics. This systematic review aims to compile and discuss the prevalence of somatostatin receptor expression in various neoplasms.

Somatostatin Receptor 3 (sst3) is a member of the superfamily of 7-transmembrane receptors that mediate the effects of somatostatins and cortistatins, with nanomolar affinity for these peptides. Its specific functions in physiology or pathology are still largely unknown. You might find these chapters and articles relevant to this topic.

A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. 这个基因编码生长抑素受体蛋白家族的一员。

Given the potent anti-proliferative, pro-apoptotic, and anti-angiogenic activities of SSTR3, targeting this receptor with a multireceptor ligand SSA such as pasireotide may be indicated for potentially aggressive GPAs. Keywords: aggressive adenoma; gonadotroph adenoma; pasireotide; somatostatin receptors. © 2015 Society for Endocrinology.

该基因编码生长抑素受体蛋白家族的一个成员。 生长抑素是调节多种细胞功能 (例如神经传递、细胞增殖和内分泌信号传导) 以及抑制许多激素和其他分泌蛋白的释放的肽类激素。 生长抑素有 14 和 28 个氨基酸的两种活性形式。 生长抑素的生物学效应由以组织特异性方式表达的 G 蛋白偶联生长抑素受体家族介导。 生长抑素受体与超家族的其他成员以及其他 G 蛋白偶联受体和受体酪氨酸激酶形成同二聚体和异二聚体。 该蛋白质在功能上与腺苷酸环化酶偶联。 交替剪接导致多个 …

2024年11月2日 · A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. Corness JD, Demchyshyn LL, Seeman P, Van Tol HH, Srikant CB, Kent G, Patel YC, Niznik HBCorness JD, et al .