2024年12月25日 · SSU72 (SSU72 Homolog, RNA Polymerase II CTD Phosphatase) is a Protein Coding gene. Diseases associated with SSU72 include 3-Methylcrotonyl-Coa Carboxylase Deficiency. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat.

2004年5月7日 · Here, we report that Ssu72, a component of the yeast cleavage/polyadenylation factor (CPF) complex, is a CTD phosphatase with specificity for S5-P. Ssu72 catalyzes CTD S5-P dephosphorylation in association with the Pta1 component of the CPF complex, although its essential role in 3' end processing is independent of catalytic activity.

2021年4月6日 · Ssu72 is a newly studied phosphatase with dual specificity that can dephosphorylate both phosphoserine/threonine and phosphotyrosine. It is important for cell-growth signaling, metabolism, and immune activation. Ssu72 was initially identified as a phosphatase for the Ser5 and Ser7 residues of the C-terminal domain of RNA polymerase II.

2025年2月8日 · Data suggest that Ssu72 is a novel cohesin-binding protein capable of regulating cohesion between sister chromatid arms. Observational study of gene-disease association. (HuGE Navigator) Molecular cloning and characterization of functions of human ssu72. Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity.

One of the many factors that assist RNAPII in transcription of genes is Ssu72. It is a carboxy-terminal-domain (CTD)-phosphatase that plays pleiotropic roles in the transcription cycle. It is essential for cell viability in Saccharomyces cerevisiae, the organism in which it was discovered.

Ssu72 is a newly studied phosphatase with dual specificity that can dephosphorylate both phosphoserine/threonine and phosphotyrosine. It is important for cell-growth signaling, metabolism, and immune activation. Ssu72 was initially identified as a phosphatase for the Ser5 and Ser7 residues of the C-terminal domain of RNA polymerase II.

2004年5月7日 · Here, we demonstrate that Ssu72 is a CTD phosphatase with specificity for S5-P. Key findings are (1) Ssu72 exhibits specificity for S5-P in vivo and in vitro, (2) Ssu72 CTD phosphatase activity is coupled to the Pta1 component of the CPF 3′ end processing complex, (3) the essential role of Ssu72 protein in 3′ end processing is independent ...

Ssu72 is a CTD phosphatase with catalytic activity against phosphorylated Ser5 and Ser7. The isomerization of Pro6 affects the binding of Ssu72 to its substrate. Ssu72 can also indirectly change the phosphorylation status of Ser2.

ssu72 同系物，rna 聚合酶 ii ctd 磷酸酶： 启用 rna 聚合酶 ii ctd 七肽重复磷酸酶活性。参与 rna 聚合酶 ii c 末端结构域的去磷酸化和 mrna 聚腺苷酸化。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

2023年2月25日 · Here, we show that Ssu72 phosphatase is essential for mRNA translation of genes required for thermogenesis in BAT. Ssu72 is found to be highly expressed in BAT among adipose tissue depots, and...