Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell cytoskeleton.

Stathmin通过与细胞内多种蛋白质相互作用,参与细胞生命过程,包括调控细胞周期、细胞运动、细胞内信号转导、胞内物质运输等。 Stathmin 由蛋白激酶,如MAPK、CDK等磷酸化调控,在微管解聚中发挥重要作用。 研究证实Stathmin 的高表达与食管癌的发生发展,对作用于微管的化疗药物的疗效相关。 现就Stathmin的结构特点、生物学功能、与其他分子的相互作用,及其与食管癌相关等方面的研究进展做一综述。 关键词:Stathmin;微管;食管癌中图分类号:R730.5 ;R735.1文献标志 …

Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival. Stathmin 1 overexpression has been reported in malignant hematopoietic cells and Stathmin 1 inhibition reduces the highly proliferative potential of leukemia cell lines.

Introduction: Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the downstream target of many signal transduction pathways. Several studies then indicated that stathmin is overexpressed in many types of human malignancies, thus deserving the name of Oncoprotein 18 (Op18).

2004年10月1日 · Stathmin is the founding member of a family of proteins that play critically important roles in the regulation of the microtubule cytoskeleton. Stathmin regulates microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.

2011年10月7日 · Stathmin 1 (also known as oncoprotein 18/Op18 or metablastin) is a cytosolic phosphoprotein firstly identified in neuroendocrine cells, by analyzing the changes of protein phosphorylation in pit...

2020年2月19日 · Studies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation...

2022年5月17日 · Stathmin1 is ubiquitous phosphoprotein, regulating microtubule stabilization. We identified the acetylation of stahtmin1 at lysine 9 (K9) in gallbladder cancer. K9 acetylation of stathmin1 was...

微管解聚蛋白Stathmin属于微管不稳定调节蛋白家族成员之一,具有促进微管解聚活性.Stathmin通过与细胞内多种蛋白质相互作用,参与细胞生命过程,包括调控细胞周期,细胞运动,细胞内信号转导,胞内物质运输等.Stathmin由蛋白激酶,如MAPK,CDK等磷酸化调控,在微管解聚中发挥重要作用.研究证实Stathmin的高表达与食管癌的发生发展,对作用于微管的化疗药物的疗效相关.现就Stathmin的结构特点,生物学功能,与其他分子的相互作用,及其与食管癌相关等方面的研究进展做一综述. 百度学 …