2021年5月27日 · For the first time, the Staudinger β-lactam synthesis was performed as a three-component reaction, by mixing diazoketones, aldehydes and amines all in once. A visible-light mediated Wolff rearrangement was the key feature for this novel multicomponent reaction.

2014年4月4日 · 叠氮盐化合物与三价的膦化合物反应、生成亚胺基膦(aza-phosphine ylide)中间体。通过水解得到伯胺的反应叫做Staudinger反应。亚胺基膦是可用作多种化学反应的中间体。也可与羰基反应生成亚胺(aza-Wittig反応)。

2024年8月23日 · This novel Ketene Three-Component Staudinger Reaction (K-3CSR) afforded a small library of β-lactams in moderate to good yields, but a drawback of this approach could be seen in the long reaction times for this batch process, indicating limited overall productivity (i.e., 48 h for imine formation and 24 h for Wolff rearrangement and ...

2021年10月1日 · Staudinger反应，又称Staudinger还原反应，由 Hermann Staudinger 发现并首先报道。 Staudinger反应是叠氮化物与膦（如三苯基膦）或亚磷酸酯反应得到亚胺基膦烷中间体，此中间体再经水解，可得相应的胺和氧化膦（如三苯基氧膦），从而提供了一种通过叠氮化物还原制 …

2021年6月14日 · For the first time, the Staudinger β-lactam synthesis was performed as a three-component reaction, by mixing diazoketones, aldehydes and amines all in once. A visible-light mediated Wolff rearrangement was the key feature for this novel multicomponent reaction.

2010年1月1日 · Multicomponent reactions (MCRs) that provide in the final product amides are suitable to produce peptides and peptide-like moieties. The Passerini and Staudinger reactions provide one amide bond, and the Ugi-four-component reaction generates two …

Strecker-3CR was used for the synthesis of ((S)-N-ethoxycarbonyl-α-methylvaline) where 3-methyl-2-butanone and NaCN were treated with NH 4 Cl in the presence of MgSO 4 in NH 3 /MeOH at 30°C. Further steps involve the formation of the tartrate salt and the preparation of (S)-2-ethoxycarbonylamino-

2021年5月27日 · The Staudinger synthesis of β-lactams from imines and ketenes has been conducted photochemically only in very limited cases. Recent advances in the visible light mediated Wolff rearrange-ment of diazoketones allowed us to perform, for the first time, a 3-component Staudinger reaction, by mixing aldehydes, amines

Another recently approved compound the cholesterol absorption inhibitor Zetia ™ (ezetimibe) is produced by a Staudinger-3CR . 239 During the Staudinger reaction a methylene active acylchloride (ketene precursor) reacts with a Schiff base formed by aldehyde and amine, likely in a stepwise cycloaddition process. 240 Although the reaction cannot ...

2022年11月27日 · In this review, we highlight groundbreaking discoveries and applications of Staudinger reactions in the molecular life sciences, starting from the engineering of the Staudinger ligation as a bioorthogonal reaction until most recent applications in modern bioconjugation methods to generate next-generation biopharmaceuticals.